InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EDN1

Summary

InnateDB Gene

IDBG-61847.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EDN1

Gene Name

endothelin 1

Synonyms

ARCND3; ET1; HDLCQ7; PPET1; QME

Species

Homo sapiens

Ensembl Gene

ENSG00000078401

Encoded Proteins

IDBP-61849

endothelin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21730058

EDN1 links TLR7 inflammatory signalling to cardiac fibrosis in autoimmune associated congenital heart block.

InnateDB Annotation from Orthologs

Summary

PMID 21730058

[Mus musculus] Edn1 links Tlr7 inflammatory signalling to cardiac fibrosis in autoimmune associated congenital heart block. (Demonstrated in human)

Entrez Gene

Summary

The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:12290363-12297194

Strand

Forward strand

Band

p24.1

Transcripts

ENST00000379375

ENSP00000368683

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0031707	endothelin A receptor binding
GO:0031708	endothelin B receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0001516	prostaglandin biosynthetic process
GO:0001569	patterning of blood vessels
GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0001821	histamine secretion
GO:0003100	regulation of systemic arterial blood pressure by endothelin
GO:0006885	regulation of pH
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007507	heart development
GO:0007585	respiratory gaseous exchange
GO:0007589	body fluid secretion
GO:0008217	regulation of blood pressure
GO:0008284	positive regulation of cell proliferation
GO:0009953	dorsal/ventral pattern formation
GO:0010193	response to ozone
GO:0010259	multicellular organismal aging
GO:0010460	positive regulation of heart rate
GO:0010595	positive regulation of endothelial cell migration
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0010870	positive regulation of receptor biosynthetic process
GO:0014032	neural crest cell development
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0014823	response to activity
GO:0014824	artery smooth muscle contraction
GO:0014826	vein smooth muscle contraction
GO:0015758	glucose transport
GO:0016049	cell growth
GO:0019229	regulation of vasoconstriction
GO:0019233	sensory perception of pain
GO:0019722	calcium-mediated signaling
GO:0030072	peptide hormone secretion
GO:0030185	nitric oxide transport
GO:0030195	negative regulation of blood coagulation
GO:0030335	positive regulation of cell migration
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0031583	phospholipase D-activating G-protein coupled receptor signaling pathway
GO:0032269	negative regulation of cellular protein metabolic process
GO:0032308	positive regulation of prostaglandin secretion
GO:0032496	response to lipopolysaccharide
GO:0033574	response to testosterone
GO:0034392	negative regulation of smooth muscle cell apoptotic process
GO:0034696	response to prostaglandin F
GO:0035094	response to nicotine
GO:0035556	intracellular signal transduction
GO:0035690	cellular response to drug
GO:0035810	positive regulation of urine volume
GO:0035815	positive regulation of renal sodium excretion
GO:0035994	response to muscle stretch
GO:0042045	epithelial fluid transport
GO:0042310	vasoconstriction
GO:0042313	protein kinase C deactivation
GO:0042474	middle ear morphogenesis
GO:0042482	positive regulation of odontogenesis
GO:0042493	response to drug
GO:0042554	superoxide anion generation
GO:0043179	rhythmic excitation
GO:0043200	response to amino acid
GO:0043406	positive regulation of MAP kinase activity
GO:0043507	positive regulation of JUN kinase activity
GO:0044321	response to leptin
GO:0045087	innate immune response (InnateDB)
GO:0045321	leukocyte activation
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045793	positive regulation of cell size
GO:0045840	positive regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045987	positive regulation of smooth muscle contraction
GO:0046887	positive regulation of hormone secretion
GO:0046888	negative regulation of hormone secretion
GO:0048016	inositol phosphate-mediated signaling
GO:0048514	blood vessel morphogenesis
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051216	cartilage development
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process
GO:0051899	membrane depolarization
GO:0051930	regulation of sensory perception of pain
GO:0060137	maternal process involved in parturition
GO:0060298	positive regulation of sarcomere organization
GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity
GO:0070101	positive regulation of chemokine-mediated signaling pathway
GO:0071277	cellular response to calcium ion
GO:0071346	cellular response to interferon-gamma
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071375	cellular response to peptide hormone stimulus
GO:0071385	cellular response to glucocorticoid stimulus
GO:0071389	cellular response to mineralocorticoid stimulus
GO:0071398	cellular response to fatty acid
GO:0071456	cellular response to hypoxia
GO:0071548	response to dexamethasone
GO:0071559	response to transforming growth factor beta
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0090023	positive regulation of neutrophil chemotaxis
GO:1902074	response to salt

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0033093	Weibel-Palade body
GO:0045178	basal part of cell
GO:0048237	rough endoplasmic reticulum lumen