Homo sapiens Gene: EDN1
Summary
InnateDB Gene IDBG-61847.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EDN1
Gene Name endothelin 1
Synonyms ARCND3; ET1; HDLCQ7; PPET1; QME;
Species Homo sapiens
Ensembl Gene ENSG00000078401
Encoded Proteins
endothelin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
EDN1 links TLR7 inflammatory signalling to cardiac fibrosis in autoimmune associated congenital heart block.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Edn1 links Tlr7 inflammatory signalling to cardiac fibrosis in autoimmune associated congenital heart block. (Demonstrated in human)
Entrez Gene
Summary The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:12290363-12297194
Strand Forward strand
Band p24.1
Transcripts
ENST00000379375 ENSP00000368683
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0031707 endothelin A receptor binding
GO:0031708 endothelin B receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0001516 prostaglandin biosynthetic process
GO:0001569 patterning of blood vessels
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001821 histamine secretion
GO:0003100 regulation of systemic arterial blood pressure by endothelin
GO:0006885 regulation of pH
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007507 heart development
GO:0007585 respiratory gaseous exchange
GO:0007589 body fluid secretion
GO:0008217 regulation of blood pressure
GO:0008284 positive regulation of cell proliferation
GO:0009953 dorsal/ventral pattern formation
GO:0010193 response to ozone
GO:0010259 multicellular organismal aging
GO:0010460 positive regulation of heart rate
GO:0010595 positive regulation of endothelial cell migration
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010870 positive regulation of receptor biosynthetic process
GO:0014032 neural crest cell development
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014823 response to activity
GO:0014824 artery smooth muscle contraction
GO:0014826 vein smooth muscle contraction
GO:0015758 glucose transport
GO:0016049 cell growth
GO:0019229 regulation of vasoconstriction
GO:0019233 sensory perception of pain
GO:0019722 calcium-mediated signaling
GO:0030072 peptide hormone secretion
GO:0030185 nitric oxide transport
GO:0030195 negative regulation of blood coagulation
GO:0030335 positive regulation of cell migration
GO:0030818 negative regulation of cAMP biosynthetic process
GO:0031583 phospholipase D-activating G-protein coupled receptor signaling pathway
GO:0032269 negative regulation of cellular protein metabolic process
GO:0032308 positive regulation of prostaglandin secretion
GO:0032496 response to lipopolysaccharide
GO:0033574 response to testosterone
GO:0034392 negative regulation of smooth muscle cell apoptotic process
GO:0034696 response to prostaglandin F
GO:0035094 response to nicotine
GO:0035556 intracellular signal transduction
GO:0035690 cellular response to drug
GO:0035810 positive regulation of urine volume
GO:0035815 positive regulation of renal sodium excretion
GO:0035994 response to muscle stretch
GO:0042045 epithelial fluid transport
GO:0042310 vasoconstriction
GO:0042313 protein kinase C deactivation
GO:0042474 middle ear morphogenesis
GO:0042482 positive regulation of odontogenesis
GO:0042493 response to drug
GO:0042554 superoxide anion generation
GO:0043179 rhythmic excitation
GO:0043200 response to amino acid
GO:0043406 positive regulation of MAP kinase activity
GO:0043507 positive regulation of JUN kinase activity
GO:0044321 response to leptin
GO:0045087 innate immune response (InnateDB)
GO:0045321 leukocyte activation
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045793 positive regulation of cell size
GO:0045840 positive regulation of mitosis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045987 positive regulation of smooth muscle contraction
GO:0046887 positive regulation of hormone secretion
GO:0046888 negative regulation of hormone secretion
GO:0048016 inositol phosphate-mediated signaling
GO:0048514 blood vessel morphogenesis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051216 cartilage development
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process
GO:0051899 membrane depolarization
GO:0051930 regulation of sensory perception of pain
GO:0060137 maternal process involved in parturition
GO:0060298 positive regulation of sarcomere organization
GO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity
GO:0070101 positive regulation of chemokine-mediated signaling pathway
GO:0071277 cellular response to calcium ion
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071375 cellular response to peptide hormone stimulus
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071389 cellular response to mineralocorticoid stimulus
GO:0071398 cellular response to fatty acid
GO:0071456 cellular response to hypoxia
GO:0071548 response to dexamethasone
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090023 positive regulation of neutrophil chemotaxis
GO:1902074 response to salt
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0033093 Weibel-Palade body
GO:0045178 basal part of cell
GO:0048237 rough endoplasmic reticulum lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Class A/1 (Rhodopsin-like receptors) pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
Melanogenesis pathway
INOH
GPCR signaling pathway
PID BIOCARTA
Role of ?-arrestins in the activation and targeting of map kinases [Biocarta view]
Hypoxia-inducible factor in the cardivascular system [Biocarta view]
Corticosteroids and cardioprotection [Biocarta view]
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway [Biocarta view]
Ss-arrestins in gpcr desensitization [Biocarta view]
G-protein signaling through tubby proteins [Biocarta view]
Nfat and hypertrophy of the heart [Biocarta view]
Chrebp regulation by carbohydrates and camp [Biocarta view]
Activation of camp-dependent protein kinase pka [Biocarta view]
Roles of ? arrestin dependent recruitment of src kinases in gpcr signaling [Biocarta view]
Ion channels and their functional role in vascular endothelium [Biocarta view]
Activation of pkc through g-protein coupled receptors [Biocarta view]
Activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor [Biocarta view]
PID NCI
AP-1 transcription factor network
Endothelins
EGFR-dependent Endothelin signaling events
HIF-1-alpha transcription factor network
Cross-References
SwissProt P05305
TrEMBL Q6FH53
UniProt Splice Variant
Entrez Gene 1906
UniGene Hs.511899
RefSeq NM_001168319 NM_001955
HUGO HGNC:3176
OMIM 131240
CCDS CCDS4522
HPRD
IMGT
EMBL AK291838 AY434104 BC009720 CH471087 CR541903 J05008 M25377 M25378 M25379 M25380 M25549 S56805 Y00749 Z98050
GenPept AAA52338 AAA52339 AAA52407 AAB25760 AAH09720 AAQ96600 BAF84527 CAA68718 CAB10846 CAG46701 EAW55314 EAW55316
RNA Seq Atlas 1906