InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PLCB2

Summary

InnateDB Gene

IDBG-6204.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLCB2

Gene Name

phospholipase C, beta 2

Synonyms

PLC-beta-2

Species

Homo sapiens

Ensembl Gene

ENSG00000137841

Encoded Proteins

IDBP-6206

phospholipase C, beta 2

IDBP-365941

phospholipase C, beta 2

IDBP-589651

phospholipase C, beta 2

IDBP-597506

phospholipase C, beta 2

IDBP-596760

phospholipase C, beta 2

IDBP-586064

phospholipase C, beta 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:40278176-40307935

Strand

Reverse strand

Band

q15.1

Transcripts

ENST00000260402	ENSP00000260402
ENST00000456256	ENSP00000411991
ENST00000560009
ENST00000559671	ENSP00000452916
ENST00000559381
ENST00000559618	ENSP00000454025
ENST00000558588
ENST00000557821	ENSP00000453975
ENST00000558505
ENST00000560701
ENST00000561378
ENST00000558409
ENST00000560093
ENST00000543785	ENSP00000444652
ENST00000559634

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004629	phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006644	phospholipid metabolic process
GO:0007165	signal transduction
GO:0007202	activation of phospholipase C activity
GO:0007268	synaptic transmission
GO:0008152	metabolic process
GO:0016042	lipid catabolic process
GO:0035556	intracellular signal transduction
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0050913	sensory perception of bitter taste

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000040061

View Gene Order

ENSBTAG00000019079

Not yet available

Pathways

NETPATH

REACTOME

REACT_18283

G alpha (q) signalling events pathway

REACT_120966

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_19145

G beta:gamma signalling through PLC beta pathway

REACT_15426

PLC beta mediated events pathway

REACT_15295

Opioid Signalling pathway

REACT_21254

Presynaptic function of Kainate receptors pathway

REACT_150312

Synthesis of IP3 and IP4 in the cytosol pathway

REACT_18405

Acetylcholine regulates insulin secretion pathway

REACT_19193

Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway

REACT_18325

Regulation of insulin secretion pathway

REACT_1505

Integration of energy metabolism pathway

REACT_172761

Ca2+ pathway pathway

REACT_172694

beta-catenin independent WNT signaling pathway

REACT_11045

Signaling by Wnt pathway

REACT_13685

Neuronal System pathway

REACT_14797

Signaling by GPCR pathway

REACT_19388

G-protein beta:gamma signalling pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_15526

G-protein mediated events pathway

REACT_21312

Activation of Kainate Receptors upon glutamate binding pathway

REACT_19375

Free fatty acids regulate insulin secretion pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_150154

Inositol phosphate metabolism pathway

REACT_15370

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

REACT_111217

Metabolism pathway

KEGG

hsa04912

GnRH signaling pathway pathway

hsa04540

Gap junction pathway

hsa04310

Wnt signaling pathway pathway

hsa00562

Inositol phosphate metabolism pathway

hsa04720

Long-term potentiation pathway

hsa05010

Alzheimer's disease pathway

hsa04070

Phosphatidylinositol signaling system pathway

hsa04742

Taste transduction pathway

hsa04730

Long-term depression pathway

hsa04020

Calcium signaling pathway pathway

hsa04916

Melanogenesis pathway

hsa04270

Vascular smooth muscle contraction pathway

hsa04062

Chemokine signaling pathway pathway

hsa05016

Huntington's disease pathway

hsa04971

Gastric acid secretion pathway

hsa05146

Amoebiasis pathway

hsa05142

Chagas disease (American trypanosomiasis) pathway

hsa04972

Pancreatic secretion pathway

hsa04970

Salivary secretion pathway

hsa05143

African trypanosomiasis pathway

hsa04973

Carbohydrate digestion and absorption pathway

INOH

INOH website

GPCR GroupI metabotropic glutamate receptor signaling pathway pathway

INOH website

GPCR signaling pathway

INOH website

Inositol phosphate metabolism pathway

PID NCI

alphasynuclein_pathway

Alpha-synuclein signaling

txa2pathway

Thromboxane A2 receptor signaling

s1p_s1p1_pathway

S1P1 pathway

il8cxcr2_pathway

IL8- and CXCR2-mediated signaling events

il8cxcr1_pathway

IL8- and CXCR1-mediated signaling events

rac1_pathway

RAC1 signaling pathway

thrombin_par4_pathway

PAR4-mediated thrombin signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.355888

RefSeq

NM_001284297 NM_001284298 NM_001284299 NM_004573 XM_005254448 XM_005254450 XM_006720571

HUGO

OMIM

CCDS

CCDS42020 CCDS61591 CCDS61592 CCDS73704

HPRD

04985

IMGT

EMBL

GenPept

RNA Seq Atlas