Version 5.4
Homo sapiens Gene: TBC1D7
Summary
InnateDB Gene IDBG-62101.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBC1D7
Gene Name TBC1 domain family, member 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000145979
Encoded Proteins
IDBP-62105
TBC1 domain family, member 7
IDBP-62107
TBC1 domain family, member 7
IDBP-62109
TBC1 domain family, member 7
IDBP-62111
TBC1 domain family, member 7
IDBP-62115
TBC1 domain family, member 7
IDBP-362372
TBC1 domain family, member 7
IDBP-362373
TBC1 domain family, member 7
IDBP-362376
TBC1 domain family, member 7
IDBP-362378
TBC1 domain family, member 7
IDBP-362381
TBC1 domain family, member 7
IDBP-362383
TBC1 domain family, member 7
IDBP-362386
TBC1 domain family, member 7
IDBP-362388
TBC1 domain family, member 7
IDBP-807659
TBC1 domain family, member 7
IDBP-807663
TBC1 domain family, member 7
IDBP-807668
TBC1 domain family, member 7
IDBP-807670
TBC1 domain family, member 7
IDBP-807673
TBC1 domain family, member 7
IDBP-807675
TBC1 domain family, member 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary TBC1D7 belongs to a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (Nakashima et al., 2007 [PubMed 17658474]).[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:13266542-13328583
Strand Reverse strand
Band p24.1
Transcripts
ENST00000343141 ENSP00000343100
ENST00000379307 ENSP00000368609
ENST00000379300 ENSP00000368602
ENST00000356436 ENSP00000348813
ENST00000379291 ENSP00000368593
ENST00000421203 ENSP00000401438
ENST00000452989 ENSP00000414292
ENST00000450347 ENSP00000404680
ENST00000422136 ENSP00000394425
ENST00000446018 ENSP00000417005
ENST00000420456 ENSP00000412102
ENST00000428109 ENSP00000414101
ENST00000416436 ENSP00000401339
ENST00000606214 ENSP00000475727
ENST00000607658 ENSP00000475191
ENST00000607532
ENST00000607208
ENST00000606370 ENSP00000475355
ENST00000606541 ENSP00000475795
ENST00000607230 ENSP00000476109
ENST00000606530 ENSP00000475469
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005097 Rab GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0031398 positive regulation of protein ubiquitination
GO:0032007 negative regulation of TOR signaling
GO:0032313 regulation of Rab GTPase activity
GO:0032851 positive regulation of Rab GTPase activity
GO:0032862 activation of Rho GTPase activity
GO:0070848 response to growth factor
Cellular Component
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021368
View Gene Order
ENSBTAG00000017160
Not yet available
Cross-References
SwissProt
TrEMBL Q5JPB9 Q5SZL3 Q5SZL5 Q5SZL6 U3KQ23
UniProt Splice Variant
Entrez Gene 51256
UniGene Hs.736993
RefSeq NM_001143964 NM_001143965 NM_001143966 NM_001258457 NM_016495 XM_005249163 XM_005249164 XM_005249166 XM_005249167 XM_006715105
HUGO HGNC:21066
OMIM 612655
CCDS CCDS4523 CCDS47376 CCDS58995
HPRD 18165
IMGT
EMBL AL008729 AL589984 AL833474
GenPept CAI46116
RNA Seq Atlas 51256

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca