Version 5.4
Homo sapiens Gene: CLIP1
Summary
InnateDB Gene IDBG-62398.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLIP1
Gene Name CAP-GLY domain containing linker protein 1
Synonyms CLIP; CLIP-170; CLIP170; CYLN1; RSN
Species Homo sapiens
Ensembl Gene ENSG00000130779
Encoded Proteins
IDBP-62400
CAP-GLY domain containing linker protein 1
IDBP-62402
CAP-GLY domain containing linker protein 1
IDBP-62404
CAP-GLY domain containing linker protein 1
IDBP-597122
CAP-GLY domain containing linker protein 1
IDBP-594603
CAP-GLY domain containing linker protein 1
IDBP-587520
CAP-GLY domain containing linker protein 1
IDBP-594423
CAP-GLY domain containing linker protein 1
IDBP-601522
CAP-GLY domain containing linker protein 1
IDBP-600481
CAP-GLY domain containing linker protein 1
IDBP-588645
CAP-GLY domain containing linker protein 1
IDBP-595058
CAP-GLY domain containing linker protein 1
IDBP-592551
CAP-GLY domain containing linker protein 1
IDBP-810948
CAP-GLY domain containing linker protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:122271432-122422632
Strand Reverse strand
Band q24.31
Transcripts
ENST00000358808 ENSP00000351665
ENST00000361654 ENSP00000355314
ENST00000302528 ENSP00000303585
ENST00000514271
ENST00000501271
ENST00000545889 ENSP00000438743
ENST00000537178 ENSP00000445531
ENST00000536634
ENST00000540539 ENSP00000437617
ENST00000538120
ENST00000540338 ENSP00000439093
ENST00000543205
ENST00000540304 ENSP00000437786
ENST00000541410
ENST00000537004 ENSP00000441409
ENST00000541108 ENSP00000446379
ENST00000535290 ENSP00000439472
ENST00000539080 ENSP00000445387
ENST00000620786 ENSP00000479322
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0015631 tubulin binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0051010 microtubule plus-end binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0001578 microtubule bundle formation
GO:0006810 transport
GO:0007067 mitotic nuclear division
GO:0031116 positive regulation of microtubule polymerization
Cellular Component
GO:0000776 kinetochore
GO:0001726 ruffle
GO:0005768 endosome
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005881 cytoplasmic microtubule
GO:0005882 intermediate filament
GO:0015630 microtubule cytoskeleton
GO:0030659 cytoplasmic vesicle membrane
GO:0035371 microtubule plus-end
GO:0044354 macropinosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049550
View Gene Order
ENSBTAG00000016779
Not yet available
Pathways
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID NCI
mtor_4pathway
mTOR signaling pathway
lis1pathway
Lissencephaly gene (LIS1) in neuronal migration and development
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.524809 Hs.682942
RefSeq NM_001247997 NM_002956 NM_198240 XM_005253593 XM_005253594 XM_005253595 XM_006719551 XM_006719552 XM_006719555
HUGO
OMIM
CCDS CCDS58285 CCDS9232 CCDS9233
HPRD 01568
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca