|Homo sapiens Gene: CD37|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||CD37 molecule|
|Useful resources||Stemformatics EHFPI ImmGen|
CD37 is important for CLEC7A (Dectin-1) stabilization in APC membranes and controls Dectin-1-mediated IL6 production.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 19:49335171-49343335|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Hematopoietic cell lineage pathway
|UniProt Splice Variant|
|RefSeq||NM_001040031 NM_001774 XM_006723511|
|RNA Seq Atlas|