Homo sapiens Gene: CD37
Summary
InnateDB Gene IDBG-62489.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD37
Gene Name CD37 molecule
Synonyms GP52-40; TSPAN26;
Species Homo sapiens
Ensembl Gene ENSG00000104894
Encoded Proteins
CD37 molecule
CD37 molecule
CD37 molecule
CD37 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CD37 is important for CLEC7A (Dectin-1) stabilization in APC membranes and controls Dectin-1-mediated IL6 production.
Entrez Gene
Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:49335171-49343335
Strand Forward strand
Band q13.33
Transcripts
ENST00000323906 ENSP00000325708
ENST00000391859 ENSP00000375732
ENST00000426897 ENSP00000413151
ENST00000535669 ENSP00000441037
ENST00000594743 ENSP00000470683
ENST00000598134
ENST00000597033
ENST00000593512
ENST00000596426
ENST00000597852
ENST00000597602 ENSP00000471078
ENST00000598095 ENSP00000470394
ENST00000595660 ENSP00000470260
ENST00000600121
ENST00000595725 ENSP00000471902
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002639 positive regulation of immunoglobulin production
GO:0002920 regulation of humoral immune response
GO:0008285 negative regulation of cell proliferation
GO:0030886 negative regulation of myeloid dendritic cell activation
GO:0042832 defense response to protozoan
GO:0045087 innate immune response (InnateDB)
GO:0050688 regulation of defense response to virus
Cellular Component
GO:0001772 immunological synapse
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Hematopoietic cell lineage pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.166556 Hs.733534
RefSeq NM_001040031 NM_001774 XM_006723511
HUGO
OMIM
CCDS CCDS12760 CCDS46139
HPRD 01053
IMGT
EMBL
GenPept
RNA Seq Atlas