Version 5.4
Homo sapiens Gene: CD37
Summary
InnateDB Gene IDBG-62489.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD37
Gene Name CD37 molecule
Synonyms GP52-40; TSPAN26
Species Homo sapiens
Ensembl Gene ENSG00000104894
Encoded Proteins
IDBP-62491
CD37 molecule
IDBP-246841
CD37 molecule
IDBP-383179
CD37 molecule
IDBP-585389
CD37 molecule
IDBP-766282
IDBP-765267
IDBP-765367
IDBP-764161
IDBP-763656
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 17182550
CD37 is important for CLEC7A (Dectin-1) stabilization in APC membranes and controls Dectin-1-mediated IL6 production.
Entrez Gene
Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:49335171-49343335
Strand Forward strand
Band q13.33
Transcripts
ENST00000323906 ENSP00000325708
ENST00000391859 ENSP00000375732
ENST00000426897 ENSP00000413151
ENST00000535669 ENSP00000441037
ENST00000594743 ENSP00000470683
ENST00000598134
ENST00000597033
ENST00000593512
ENST00000596426
ENST00000597852
ENST00000597602 ENSP00000471078
ENST00000598095 ENSP00000470394
ENST00000595660 ENSP00000470260
ENST00000600121
ENST00000595725 ENSP00000471902
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002639 positive regulation of immunoglobulin production
GO:0002920 regulation of humoral immune response
GO:0008285 negative regulation of cell proliferation
GO:0030886 negative regulation of myeloid dendritic cell activation
GO:0042832 defense response to protozoan
GO:0045087 innate immune response (InnateDB)
GO:0050688 regulation of defense response to virus
Cellular Component
GO:0001772 immunological synapse
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030798
View Gene Order
ENSBTAG00000011421
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04640
Hematopoietic cell lineage pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 951
UniGene Hs.166556 Hs.733534
RefSeq NM_001040031 NM_001774 XM_006723511
HUGO HGNC:1666
OMIM 151523
CCDS CCDS12760 CCDS46139
HPRD 01053
IMGT
EMBL
GenPept
RNA Seq Atlas 951

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca