InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TBX2

Summary

InnateDB Gene

IDBG-62492.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TBX2

Gene Name

T-box 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000121068

Encoded Proteins

IDBP-62494

T-box 2

IDBP-382684

T-box 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:61399896-61409466

Strand

Forward strand

Band

q23.2

Transcripts

ENST00000240328	ENSP00000240328
ENST00000419047	ENSP00000404781
ENST00000477081
ENST00000586986

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0003007	heart morphogenesis
GO:0003148	outflow tract septum morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0003203	endocardial cushion morphogenesis
GO:0003256	regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007521	muscle cell fate determination
GO:0007569	cell aging
GO:0008284	positive regulation of cell proliferation
GO:0035909	aorta morphogenesis
GO:0036302	atrioventricular canal development
GO:0042733	embryonic digit morphogenesis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048596	embryonic camera-type eye morphogenesis
GO:0048738	cardiac muscle tissue development
GO:0060021	palate development
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060465	pharynx development
GO:0060560	developmental growth involved in morphogenesis
GO:0060596	mammary placode formation
GO:0090398	cellular senescence
GO:1901208	negative regulation of heart looping
GO:1901211	negative regulation of cardiac chamber formation

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000000093

View Gene Order

ENSBTAG00000014278

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.531085 Hs.669281

RefSeq

NM_005994

HUGO

OMIM

CCDS

CCDS11627

HPRD

02850

IMGT

EMBL

GenPept

RNA Seq Atlas