Version 5.4
Bos taurus Gene: BT.28672
Summary
InnateDB Gene IDBG-628828.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.28672
Gene Name double-strand break repair protein MRE11A
Synonyms MRE11A
Species Bos taurus
Ensembl Gene ENSBTAG00000008925
Encoded Proteins
IDBP-680205
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000020922:
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3\' to 5\' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3\' to 5\' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:1640852-1716775
Strand Reverse strand
Band
Transcripts
ENSBTAT00000011748 ENSBTAP00000011748
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
Predicted by orthology
Total 53 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008408 3'-5' exonuclease activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
Biological Process
GO:0000723 telomere maintenance
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006289 nucleotide-excision repair
GO:0006302 double-strand break repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007062 sister chromatid cohesion
GO:0007095 mitotic G2 DNA damage checkpoint
GO:0007126 meiotic nuclear division
GO:0007129 synapsis
GO:0008283 cell proliferation
GO:0031573 intra-S DNA damage checkpoint
GO:0031954 positive regulation of protein autophosphorylation
GO:0032508 DNA duplex unwinding
GO:0032876 negative regulation of DNA endoreduplication
GO:0033674 positive regulation of kinase activity
GO:0051276 chromosome organization
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0030870 Mre11 complex
GO:0035861 site of double-strand break
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000020922
View Gene Order
ENSMUSG00000031928
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_147841
STING mediated induction of host immune responses pathway
REACT_486
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks pathway
REACT_1884
MRN complex relocalizes to nuclear foci pathway
REACT_97
Recruitment of repair and signaling proteins to double-strand breaks pathway
REACT_27271
Meiotic recombination pathway
REACT_120956
Cellular responses to stress pathway
REACT_163993
IRF3-mediated induction of type I IFN pathway
REACT_1874
Homologous Recombination Repair pathway
REACT_6802
Innate Immune System pathway
REACT_2054
Double-Strand Break Repair pathway
REACT_115566
Cell Cycle pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_1587
Homologous recombination repair of replication-independent double-strand breaks pathway
REACT_111183
Meiosis pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_216
DNA Repair pathway
REACT_239142
Innate Immune System pathway
REACT_230172
Recruitment of repair and signaling proteins to double-strand breaks pathway
REACT_261629
MRN complex relocalizes to nuclear foci pathway
REACT_188957
Cellular responses to stress pathway
REACT_188819
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_238355
Double-Strand Break Repair pathway
REACT_256555
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks pathway
REACT_230745
Immune System pathway
REACT_233397
DNA Repair pathway
REACT_188820
Cellular Senescence pathway
REACT_196447
IRF3-mediated induction of type I IFN pathway
REACT_218897
Cytosolic sensors of pathogen-associated DNA pathway
REACT_196457
STING mediated induction of host immune responses pathway
REACT_245922
Homologous Recombination Repair pathway
REACT_251264
Homologous recombination repair of replication-independent double-strand breaks pathway
KEGG
hsa03450
Non-homologous end-joining pathway
hsa03440
Homologous recombination pathway
mmu03440
Homologous recombination pathway
mmu03450
Non-homologous end-joining pathway
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
bard1pathway
BARD1 signaling events
atm_pathway
ATM pathway
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL E1BIN9
UniProt Splice Variant
Entrez Gene 525093
UniGene Bt.28672
RefSeq NM_001192605
HUGO HGNC:7230
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02039761 DAAA02039762 DAAA02039763 DAAA02039764 DAAA02039765
GenPept
RNA Seq Atlas 525093

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca