InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TLK2

Summary

InnateDB Gene

IDBG-62909.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TLK2

Gene Name

tousled-like kinase 2

Synonyms

HsHPK; PKU-ALPHA

Species

Homo sapiens

Ensembl Gene

ENSG00000146872

Encoded Proteins

IDBP-62911

tousled-like kinase 2

IDBP-62913

tousled-like kinase 2

IDBP-62915

tousled-like kinase 2

IDBP-603959

tousled-like kinase 2

IDBP-763163

IDBP-759187

IDBP-760840

IDBP-758003

IDBP-758596

IDBP-759785

IDBP-764175

IDBP-764525

IDBP-813288

tousled-like kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM, Apr 2004]
This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:62458658-62615481

Strand

Forward strand

Band

q23.2

Transcripts

ENST00000326270	ENSP00000316512
ENST00000346027	ENSP00000275780
ENST00000343388	ENSP00000340800
ENST00000542523	ENSP00000442311
ENST00000577616
ENST00000584367
ENST00000582809	ENSP00000463595
ENST00000580203
ENST00000582195	ENSP00000462637
ENST00000581286
ENST00000578931
ENST00000581041	ENSP00000462036
ENST00000582660
ENST00000578697	ENSP00000462851
ENST00000583843	ENSP00000463814
ENST00000583310
ENST00000583690	ENSP00000463986
ENST00000580705	ENSP00000464516
ENST00000579450	ENSP00000464557
ENST00000619310	ENSP00000482427

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001672	regulation of chromatin assembly or disassembly
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0007049	cell cycle
GO:0007059	chromosome segregation
GO:0010507	negative regulation of autophagy
GO:0016568	chromatin modification
GO:0018105	peptidyl-serine phosphorylation
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035556	intracellular signal transduction
GO:0071480	cellular response to gamma radiation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005882	intermediate filament
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020694

View Gene Order

ENSBTAG00000015713

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.445078 Hs.611380 Hs.714158

RefSeq

NM_001284333 NM_001284363 NM_006852 XM_005256969 XM_005256970 XM_005256971 XM_005256973 XM_005256974 XM_005256975 XM_006721647 XM_006721648

HUGO

OMIM

CCDS

CCDS11633 CCDS45753 CCDS62283

HPRD

10527

IMGT

EMBL

GenPept

RNA Seq Atlas