Version 5.4
Homo sapiens Gene: DISP2
Summary
InnateDB Gene IDBG-6294.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DISP2
Gene Name dispatched homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000140323
Encoded Proteins
IDBP-6296
dispatched homolog 2 (Drosophila)
IDBP-583388
dispatched homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:40358235-40371056
Strand Forward strand
Band q15.1
Transcripts
ENST00000267889 ENSP00000267889
ENST00000559721
ENST00000558623 ENSP00000453984
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007224 smoothened signaling pathway
Cellular Component
GO:0005575 cellular_component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040035
View Gene Order
ENSBTAG00000000552
Not yet available
Pathways
NETPATH
REACTOME
REACT_228190
Processing-defective Hh variants abrogate ligand secretion pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_228239
Release of Hh-Np from the secreting cell pathway
REACT_111102
Signal Transduction pathway
REACT_228111
Hedgehog ligand biogenesis pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.355645
RefSeq NM_033510
HUGO
OMIM
CCDS CCDS10056
HPRD 06327
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca