Version 5.4
Bos taurus Gene: THAP1
Summary
InnateDB Gene IDBG-629979.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THAP1
Gene Name THAP domain-containing protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007629
Encoded Proteins
IDBP-681408
THAP domain-containing protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131931:
The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 27:37234389-37240538
Strand Reverse strand
Band
Transcripts
ENSBTAT00000010035 ENSBTAP00000010035
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0001935 endothelial cell proliferation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007049 cell cycle
GO:0007346 regulation of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016605 PML body
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000131931
View Gene Order
ENSMUSG00000037214
View Gene Order
Cross-References
SwissProt Q3T0G1
TrEMBL
UniProt Splice Variant
Entrez Gene 538615
UniGene Bt.46092
RefSeq NM_001034648
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102409
GenPept AAI02410
RNA Seq Atlas 538615

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca