Version 5.4
Homo sapiens Gene: MYLIP
Summary
InnateDB Gene IDBG-63017.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYLIP
Gene Name myosin regulatory light chain interacting protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000007944
Encoded Proteins
IDBP-63019
myosin regulatory light chain interacting protein
IDBP-63021
myosin regulatory light chain interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:16129125-16148248
Strand Forward strand
Band p22.3
Transcripts
ENST00000349606 ENSP00000008686
ENST00000356840 ENSP00000349298
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 23 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0006928 cellular component movement
GO:0007399 nervous system development
GO:0010989 negative regulation of low-density lipoprotein particle clearance
GO:0016567 protein ubiquitination
GO:0031648 protein destabilization
GO:0032803 regulation of low-density lipoprotein particle receptor catabolic process
GO:0042632 cholesterol homeostasis
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0045732 positive regulation of protein catabolic process
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0019898 extrinsic component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038175
View Gene Order
ENSBTAG00000004115
Not yet available
Cross-References
SwissProt Q8WY64
TrEMBL Q5TIA5
UniProt Splice Variant
Entrez Gene 29116
UniGene Hs.484738 Hs.653717
RefSeq NM_013262 XM_005249033
HUGO HGNC:21155
OMIM 610082
CCDS CCDS4536
HPRD
IMGT
EMBL AF006003 AF006004 AF187016 AF212221 AF258586 AL021407 BC002860 BT007055 CH471087
GenPept AAF18974 AAF87323 AAG23789 AAH02860 AAP35704 AAQ13408 AAQ13409 CAI19548 EAW55366 EAW55367
RNA Seq Atlas 29116

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca