InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PIM1

Summary

InnateDB Gene

IDBG-630304.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIM1

Gene Name

Serine/threonine-protein kinase pim-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000396

Encoded Proteins

IDBP-681755

Proto-oncogene serine/threonine-protein kinase pim-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137193:
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:11051544-11055416

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000511

ENSBTAP00000000511

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0030145	manganese ion binding
GO:0043024	ribosomal small subunit binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0008283	cell proliferation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0016310	phosphorylation
GO:0031659	positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0043066	negative regulation of apoptotic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0046777	protein autophosphorylation