Version 5.4
Homo sapiens Gene: NUMA1
Summary
InnateDB Gene IDBG-63041.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUMA1
Gene Name nuclear mitotic apparatus protein 1
Synonyms NUMA
Species Homo sapiens
Ensembl Gene ENSG00000137497
Encoded Proteins
IDBP-63045
nuclear mitotic apparatus protein 1
IDBP-63047
nuclear mitotic apparatus protein 1
IDBP-95117
nuclear mitotic apparatus protein 1
IDBP-583939
nuclear mitotic apparatus protein 1
IDBP-243097
nuclear mitotic apparatus protein 1
IDBP-603813
nuclear mitotic apparatus protein 1
IDBP-587238
nuclear mitotic apparatus protein 1
IDBP-587181
nuclear mitotic apparatus protein 1
IDBP-600130
nuclear mitotic apparatus protein 1
IDBP-590121
nuclear mitotic apparatus protein 1
IDBP-585550
nuclear mitotic apparatus protein 1
IDBP-603275
nuclear mitotic apparatus protein 1
IDBP-584348
nuclear mitotic apparatus protein 1
IDBP-589498
nuclear mitotic apparatus protein 1
IDBP-587967
nuclear mitotic apparatus protein 1
IDBP-598086
nuclear mitotic apparatus protein 1
IDBP-598085
nuclear mitotic apparatus protein 1
IDBP-593113
nuclear mitotic apparatus protein 1
IDBP-590766
nuclear mitotic apparatus protein 1
IDBP-596615
nuclear mitotic apparatus protein 1
IDBP-603283
nuclear mitotic apparatus protein 1
IDBP-807150
nuclear mitotic apparatus protein 1
IDBP-807153
nuclear mitotic apparatus protein 1
IDBP-807154
nuclear mitotic apparatus protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:72002864-72080693
Strand Reverse strand
Band q13.4
Transcripts
ENST00000358965 ENSP00000351851
ENST00000351960 ENSP00000260051
ENST00000368959 ENSP00000357955
ENST00000366394 ENSP00000438318
ENST00000393695 ENSP00000377298
ENST00000540626
ENST00000541584 ENSP00000440954
ENST00000541262
ENST00000545721 ENSP00000446396
ENST00000546036
ENST00000540588
ENST00000542977 ENSP00000444880
ENST00000537217 ENSP00000442936
ENST00000534987
ENST00000540843
ENST00000536119
ENST00000544238 ENSP00000442761
ENST00000543937 ENSP00000439759
ENST00000543009 ENSP00000438821
ENST00000537930 ENSP00000438589
ENST00000544129 ENSP00000439092
ENST00000535947 ENSP00000444175
ENST00000534971
ENST00000535087 ENSP00000439576
ENST00000541719 ENSP00000438331
ENST00000541641 ENSP00000441598
ENST00000537905
ENST00000535111 ENSP00000441674
ENST00000535838 ENSP00000444831
ENST00000546131 ENSP00000442331
ENST00000543450
ENST00000620566 ENSP00000478624
ENST00000616538 ENSP00000481541
ENST00000613205 ENSP00000480172
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 78 [view]
Protein-Protein 76 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0008017 microtubule binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000090 mitotic anaphase
GO:0000132 establishment of mitotic spindle orientation
GO:0000278 mitotic cell cycle
GO:0006997 nucleus organization
GO:0007067 mitotic nuclear division
GO:0051321 meiotic cell cycle
GO:0060487 lung epithelial cell differentiation
Cellular Component
GO:0000139 Golgi membrane
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005876 spindle microtubule
GO:0016363 nuclear matrix
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000066306
View Gene Order
ENSBTAG00000018449
Not yet available
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
REACT_15510
Recruitment of NuMA to mitotic centrosomes pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_115566
Cell Cycle pathway
REACT_15479
Centrosome maturation pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.325978 Hs.594032 Hs.632934
RefSeq NM_001286561 NM_006185 XM_006718562 XM_006718563 XM_006718564 XM_006718565 XM_006718566 XM_006718567 XM_006718568 XM_006718569 XM_006718570
HUGO
OMIM
CCDS CCDS31633 CCDS66156
HPRD 01236
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca