Version 5.4
Bos taurus Gene: FREM1
Summary
InnateDB Gene IDBG-630756.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FREM1
Gene Name FRAS1-related extracellular matrix protein 1 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020141
Encoded Proteins
IDBP-682255
FRAS1 related extracellular matrix 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 22262840
[Homo sapiens] FREM1 selectively amplifies NF-kB responses, such as cell survival and inflammatory responses, through changes in receptor conformation and adapter protein recruitment.
PMID 22262840
[Mus musculus] Frem1 selectively amplifies NF-kB responses, such as cell survival and inflammatory responses, through changes in receptor conformation and adapter protein recruitment. (Demonstrated in human)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164946:
This gene encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described. PubMed ID 19940113 describes one such variant that initiates transcription within a distinct, internal exon; the resulting shorter isoform (named Toll-like/interleukin-1 receptor regulator, TILRR) is suggested to be a co-receptor of the interleukin 1 receptor family and may regulate receptor function and Toll-like receptor/interleukin 1 receptor signal transduction, contributing to the control of inflammatory response activation. [provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:29353418-29504029
Strand Forward strand
Band
Transcripts
ENSBTAT00000026827 ENSBTAP00000026827
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003993 acid phosphatase activity
GO:0005509 calcium ion binding
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0007154 cell communication
GO:0007160 cell-matrix adhesion
GO:0097094 craniofacial suture morphogenesis
Cellular Component
GO:0005604 basement membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000164946
View Gene Order
ENSMUSG00000059049
View Gene Order
Cross-References
SwissProt
TrEMBL E1BN52
UniProt Splice Variant
Entrez Gene 508018
UniGene Bt.70226
RefSeq NM_001192995 XM_005209921
HUGO HGNC:23399
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02022402 DAAA02022403 DAAA02022404 DAAA02022405
GenPept
RNA Seq Atlas 508018

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca