Version 5.4
Homo sapiens Gene: MARCH10
Summary
InnateDB Gene IDBG-63104.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARCH10
Gene Name membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000173838
Encoded Proteins
IDBP-63106
membrane-associated ring finger (C3HC4) 10
IDBP-382817
membrane-associated ring finger (C3HC4) 10
IDBP-603955
membrane-associated ring finger (C3HC4) 10
IDBP-763353
IDBP-761560
IDBP-757927
IDBP-760285
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:62701314-62808344
Strand Reverse strand
Band q23.2
Transcripts
ENST00000311269 ENSP00000311496
ENST00000456609 ENSP00000416177
ENST00000544856 ENSP00000443746
ENST00000582358
ENST00000582568 ENSP00000463572
ENST00000583803 ENSP00000463029
ENST00000578346
ENST00000580520 ENSP00000464220
ENST00000579620
ENST00000583600 ENSP00000463080
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000078627
View Gene Order
ENSBTAG00000004637
Not yet available
Cross-References
SwissProt Q8NA82
TrEMBL G3V1Q5 J3KTK3 J3KTN9 J3QLJ2
UniProt Splice Variant
Entrez Gene 162333
UniGene Hs.665663 Hs.710548
RefSeq NM_001100875 NM_001288779 NM_001288780 NM_152598 XM_005257103 XM_005257105 XM_005257106
HUGO HGNC:26655
OMIM 613337
CCDS CCDS11635 CCDS74122 CCDS74123
HPRD
IMGT
EMBL AC005821 AC068512 AC080038 AK093076 AK097506 BC035021 CH471109
GenPept AAH35021 BAC04044 BAC05079 EAW94337 EAW94338 EAW94339 EAW94340
RNA Seq Atlas 162333

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca