Version 5.4
Bos taurus Gene: FBXO22
Summary
InnateDB Gene IDBG-631183.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO22
Gene Name F-box only protein 22
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002833
Encoded Proteins
IDBP-682693
F-box only protein 22
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167196:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:31714324-31740279
Strand Forward strand
Band
Transcripts
ENSBTAT00000003665 ENSBTAP00000003665
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006913 nucleocytoplasmic transport
GO:0009267 cellular response to starvation
GO:0010830 regulation of myotube differentiation
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0048742 regulation of skeletal muscle fiber development
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000167196
View Gene Order
ENSMUSG00000032309
View Gene Order
Cross-References
SwissProt
TrEMBL A5PJX0
UniProt Splice Variant
Entrez Gene 536605
UniGene Bt.41466
RefSeq NM_001099074
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142269 DAAA02052440
GenPept AAI42270
RNA Seq Atlas 536605

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca