Version 5.4
Bos taurus Gene: HOXC11
Summary
InnateDB Gene IDBG-631210.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOXC11
Gene Name homeobox protein Hox-C11
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006879
Encoded Proteins
IDBP-682722
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123388:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:26215737-26218209
Strand Reverse strand
Band
Transcripts
ENSBTAT00000009028 ENSBTAP00000009028
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001501 skeletal system development
GO:0001656 metanephros development
GO:0001759 organ induction
GO:0006355 regulation of transcription, DNA-templated
GO:0009952 anterior/posterior pattern specification
GO:0009954 proximal/distal pattern formation
GO:0042733 embryonic digit morphogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060272 embryonic skeletal joint morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000123388
View Gene Order
ENSMUSG00000001656
View Gene Order
Cross-References
SwissProt
TrEMBL F1MZ11 Q0V8G7
UniProt Splice Variant
Entrez Gene 536141
UniGene Bt.30875
RefSeq NM_001192873 XM_005206160
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT026251 DAAA02012843
GenPept ABG67090
RNA Seq Atlas 536141

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca