InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ASCC3

Summary

InnateDB Gene

IDBG-631979.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASCC3

Gene Name

Activating signal cointegrator 1 complex subunit 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020482

Encoded Proteins

IDBP-683567

activating signal cointegrator 1 complex subunit 3

IDBP-683632

activating signal cointegrator 1 complex subunit 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23781071

[Homo sapiens] ASCC3 inhibits IFN-signalling to dampen antiviral innate immunity.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112249:
This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:49714504-50103135

Strand

Forward strand

Band

Transcripts

ENSBTAT00000065100	ENSBTAP00000054643
ENSBTAT00000027294	ENSBTAP00000027294

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0043140	ATP-dependent 3'-5' DNA helicase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006281	DNA repair
GO:0006307	DNA dealkylation involved in DNA repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0008283	cell proliferation
GO:0032508	DNA duplex unwinding

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000112249

View Gene Order

ENSMUSG00000038774

View Gene Order

Cross-References

SwissProt

E1BNG3

TrEMBL

G3MYK8

UniProt Splice Variant

Entrez Gene

538416

UniGene

Bt.26262

RefSeq

NM_001206118

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02026160 DAAA02026161 DAAA02026162 DAAA02026163 DAAA02026164 DAAA02026165 DAAA02026166 DAAA02026167 DAAA02026168 DAAA02026169 DAAA02026170 DAAA02026171 DAAA02026172 DAAA02026173 DAAA02026174 DAAA02026175 DAAA02026176 DAAA02026177 DAAA02026178 DAAA02026179 DAAA02026180 DAAA02026181 DAAA02026182 DAAA02026183 DAAA02026184 DAAA02026185 DAAA02026186 DAAA02026187 DAAA02026188 DAAA02026189 DAAA02026190 DAAA02026191 DAAA02026192 DAAA02026193 DAAA02026194 DAAA02026195 DAAA02026196 DAAA02026197 DAAA02026198 DAAA02026199

GenPept

RNA Seq Atlas

538416