Bos taurus Gene: BT.28710
InnateDB Gene IDBG-632173.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.28710
Gene Name serine/threonine-protein kinase receptor R3 precursor
Species Bos taurus
Ensembl Gene ENSBTAG00000013843
Encoded Proteins
serine/threonine-protein kinase receptor R3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139567:
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:28097837-28106733
Strand Reverse strand
ENSBTAT00000018383 ENSBTAP00000018383
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005025 transforming growth factor beta receptor activity, type I
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016361 activin receptor activity, type I
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0046332 SMAD binding
GO:0048185 activin binding
GO:0050431 transforming growth factor beta binding
Biological Process
GO:0001525 angiogenesis
GO:0001701 in utero embryonic development
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001946 lymphangiogenesis
GO:0001974 blood vessel remodeling
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007162 negative regulation of cell adhesion
GO:0007165 signal transduction
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008015 blood circulation
GO:0008217 regulation of blood pressure
GO:0008285 negative regulation of cell proliferation
GO:0010596 negative regulation of endothelial cell migration
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016310 phosphorylation
GO:0023014 signal transduction by phosphorylation
GO:0030308 negative regulation of cell growth
GO:0030336 negative regulation of cell migration
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0032924 activin receptor signaling pathway
GO:0035313 wound healing, spreading of epidermal cells
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045602 negative regulation of endothelial cell differentiation
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048514 blood vessel morphogenesis
GO:0051895 negative regulation of focal adhesion assembly
GO:0060836 lymphatic endothelial cell differentiation
GO:0060840 artery development
GO:0060841 venous blood vessel development
GO:0061154 endothelial tube morphogenesis
GO:0061298 retina vasculature development in camera-type eye
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071773 cellular response to BMP stimulus
GO:2000279 negative regulation of DNA biosynthetic process
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
TGF_beta_Receptor pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
TGF-beta signaling pathway
BMP2 signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
BMP2 signaling pathway
TGF-beta signaling pathway
ALK1 pathway
ALK1 signaling events
UniProt Splice Variant
Entrez Gene 534536
UniGene Bt.28710
RefSeq NM_001083479 XM_005206223 XM_005206224
EMBL DAAA02012896
RNA Seq Atlas 534536