InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.28710

Summary

InnateDB Gene

IDBG-632173.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.28710

Gene Name

serine/threonine-protein kinase receptor R3 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013843

Encoded Proteins

IDBP-683768

serine/threonine-protein kinase receptor R3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139567:
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:28097837-28106733

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000018383

ENSBTAP00000018383

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005025	transforming growth factor beta receptor activity, type I
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016361	activin receptor activity, type I
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0046332	SMAD binding
GO:0048185	activin binding
GO:0050431	transforming growth factor beta binding

Biological Process

GO:0001525	angiogenesis
GO:0001701	in utero embryonic development
GO:0001937	negative regulation of endothelial cell proliferation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0001946	lymphangiogenesis
GO:0001974	blood vessel remodeling
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007162	negative regulation of cell adhesion
GO:0007165	signal transduction
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008015	blood circulation
GO:0008217	regulation of blood pressure
GO:0008285	negative regulation of cell proliferation
GO:0010596	negative regulation of endothelial cell migration
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016310	phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0030308	negative regulation of cell growth
GO:0030336	negative regulation of cell migration
GO:0030509	BMP signaling pathway
GO:0030513	positive regulation of BMP signaling pathway
GO:0032924	activin receptor signaling pathway
GO:0035313	wound healing, spreading of epidermal cells
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0045602	negative regulation of endothelial cell differentiation
GO:0045603	positive regulation of endothelial cell differentiation
GO:0045766	positive regulation of angiogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048514	blood vessel morphogenesis
GO:0051895	negative regulation of focal adhesion assembly
GO:0060836	lymphatic endothelial cell differentiation
GO:0060840	artery development
GO:0060841	venous blood vessel development
GO:0061154	endothelial tube morphogenesis
GO:0061298	retina vasculature development in camera-type eye
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0071773	cellular response to BMP stimulus
GO:2000279	negative regulation of DNA biosynthetic process