Version 5.4
Bos taurus Gene: CELA1
Summary
InnateDB Gene IDBG-632294.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CELA1
Gene Name Chymotrypsin-like elastase family member 1
Synonyms ELA1
Species Bos taurus
Ensembl Gene ENSBTAG00000008900
Encoded Proteins
IDBP-683898
Chymotrypsin-like elastase family member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139610:
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. To date, elastase 1 expression has only been detected in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:28622128-28637016
Strand Forward strand
Band
Transcripts
ENSBTAT00000011718 ENSBTAP00000011718
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006508 proteolysis
GO:0006954 inflammatory response
GO:0009791 post-embryonic development
GO:0016055 Wnt signaling pathway
GO:0031017 exocrine pancreas development
GO:0035264 multicellular organism growth
GO:0042127 regulation of cell proliferation
GO:0045595 regulation of cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0055123 digestive system development
GO:0061113 pancreas morphogenesis
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000139610
View Gene Order
ENSMUSG00000023031
View Gene Order
Cross-References
SwissProt Q28153
TrEMBL
UniProt Splice Variant
Entrez Gene 281139
UniGene Bt.4522
RefSeq NM_174048 XM_005206256
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC149525 M80838
GenPept AAA98525 AAI49526
RNA Seq Atlas 281139

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca