Version 5.4
Bos taurus Gene: CRTC2
Summary
InnateDB Gene IDBG-632643.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRTC2
Gene Name CREB-regulated transcription coactivator 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017942
Encoded Proteins
IDBP-684280
CREB-regulated transcription coactivator 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160741:
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:16535366-16544863
Strand Forward strand
Band
Transcripts
ENSBTAT00000056382 ENSBTAP00000050880
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008140 cAMP response element binding protein binding
Biological Process
GO:0006094 gluconeogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0032793 positive regulation of CREB transcription factor activity
GO:0042593 glucose homeostasis
GO:0043970 histone H3-K9 acetylation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051289 protein homotetramerization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000160741
View Gene Order
ENSMUSG00000027936
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
lkb1_pathway
LKB1 signaling events
Cross-References
SwissProt Q08E26
TrEMBL
UniProt Splice Variant
Entrez Gene 540959
UniGene Bt.27312
RefSeq NM_001076250
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123454
GenPept AAI23455
RNA Seq Atlas 540959

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca