InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FOXP2

Summary

InnateDB Gene

IDBG-632860.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXP2

Gene Name

forkhead box protein P2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011246

Encoded Proteins

IDBP-684556

forkhead box P2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128573:
This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:54087329-54164075

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000014933

ENSBTAP00000014933

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0006355	regulation of transcription, DNA-templated
GO:0007519	skeletal muscle tissue development
GO:0009791	post-embryonic development
GO:0021549	cerebellum development
GO:0021757	caudate nucleus development
GO:0021758	putamen development
GO:0021987	cerebral cortex development
GO:0030324	lung development
GO:0040007	growth
GO:0042297	vocal learning
GO:0043010	camera-type eye development
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048286	lung alveolus development
GO:0048745	smooth muscle tissue development
GO:0050679	positive regulation of epithelial cell proliferation
GO:0060013	righting reflex
GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis

Cellular Component

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000128573

View Gene Order

ENSMUSG00000029563

View Gene Order

Cross-References

SwissProt

TrEMBL

F1N4J3

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

HGNC:13875

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02010648

GenPept

RNA Seq Atlas