Bos taurus Gene: P2RX4
InnateDB Gene IDBG-633036.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P2RX4
Gene Name P2X purinoceptor 4
Species Bos taurus
Ensembl Gene ENSBTAG00000010812
Encoded Proteins
P2X purinoceptor 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135124:
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:56173049-56189197
Strand Reverse strand
ENSBTAT00000014321 ENSBTAP00000014321
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001614 purinergic nucleotide receptor activity
GO:0004931 extracellular ATP-gated cation channel activity
GO:0005216 ion channel activity
GO:0005524 ATP binding
GO:0045296 cadherin binding
Biological Process
GO:0006809 nitric oxide biosynthetic process
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0006816 calcium ion transport
GO:0007165 signal transduction
GO:0008217 regulation of blood pressure
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0033198 response to ATP
GO:0034220 ion transmembrane transport
GO:0034405 response to fluid shear stress
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0042311 vasodilation
GO:0050850 positive regulation of calcium-mediated signaling
GO:0051899 membrane depolarization
GO:0055117 regulation of cardiac muscle contraction
GO:0055119 relaxation of cardiac muscle
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0071318 cellular response to ATP
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005639 integral component of nuclear inner membrane
GO:0005765 lysosomal membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0045177 apical part of cell
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
Neuroactive ligand-receptor interaction pathway
Calcium signaling pathway pathway
Calcium signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
SwissProt Q5E9U1
UniProt Splice Variant
Entrez Gene 338036
UniGene Bt.15997
RefSeq NM_001034049 XM_005217747
EMBL BC120340 BT020829
GenPept AAI20341 AAX08846
RNA Seq Atlas 338036