InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TRPV1

Summary

InnateDB Gene

IDBG-633225.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPV1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018880

Encoded Proteins

IDBP-684950

transient receptor potential cation channel, subfamily V, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000262304:
The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008] Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5\' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:24890751-24913053

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000025131

ENSBTAP00000025131

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding

Biological Process

GO:0001659	temperature homeostasis
GO:0001660	fever generation
GO:0002024	diet induced thermogenesis
GO:0002790	peptide secretion
GO:0006629	lipid metabolic process
GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0009268	response to pH
GO:0009408	response to heat
GO:0010243	response to organonitrogen compound
GO:0014832	urinary bladder smooth muscle contraction
GO:0019233	sensory perception of pain
GO:0042637	catagen
GO:0048265	response to pain
GO:0048266	behavioral response to pain
GO:0050954	sensory perception of mechanical stimulus
GO:0050968	detection of chemical stimulus involved in sensory perception of pain
GO:0055085	transmembrane transport
GO:0060083	smooth muscle contraction involved in micturition

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043005	neuron projection

Orthologs

Species

Mus musculus

Homo sapiens

Gene ID

Gene Order

ENSMUSG00000005952

View Gene Order

ENSG00000262304

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_196640

Stimuli-sensing channels pathway

REACT_262350

Ion channel transport pathway

REACT_253400

Transmembrane transport of small molecules pathway

REACT_227861

TRP channels pathway

KEGG

mmu04080

Neuroactive ligand-receptor interaction pathway

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E1BGM0

UniProt Splice Variant

Entrez Gene

539074

UniGene

RefSeq

XM_002695751 XM_863847

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02048691

GenPept

RNA Seq Atlas

539074