Bos taurus Gene: E2F4
Summary
InnateDB Gene IDBG-633347.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol E2F4
Gene Name transcription factor E2F4
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012063
Encoded Proteins
transcription factor E2F4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000205250:
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:34947877-34954517
Strand Forward strand
Band
Transcripts
ENSBTAT00000015999 ENSBTAP00000015999
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 91 interaction(s) predicted by orthology.
Predicted by orthology
Total 91 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019904 protein domain specific binding
Biological Process
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0002064 epithelial cell development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006884 cell volume homeostasis
GO:0008015 blood circulation
GO:0008361 regulation of cell size
GO:0009887 organ morphogenesis
GO:0042127 regulation of cell proliferation
GO:0042384 cilium assembly
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
TGF_beta_Receptor pathway
REACTOME
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
G1 Phase pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Mitotic G1-G1/S phases pathway
Cyclin D associated events in G1 pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Cell Cycle pathway
Generic Transcription Pathway pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
G0 and Early G1 pathway
TGFBR1 KD Mutants in Cancer pathway
Cell Cycle, Mitotic pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Gene Expression pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Cell Cycle, Mitotic pathway
G1 Phase pathway
Disease pathway
Loss of Function of SMAD4 in Cancer pathway
G0 and Early G1 pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Cell Cycle pathway
Cyclin D associated events in G1 pathway
Loss of Function of TGFBR2 in Cancer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Mitotic G1-G1/S phases pathway
Gene Expression pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Generic Transcription Pathway pathway
Signal Transduction pathway
TGFBR1 KD Mutants in Cancer pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
Signaling by TGF-beta Receptor Complex pathway
Loss of Function of SMAD2/3 in Cancer pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
KEGG
Cell cycle pathway
TGF-beta signaling pathway pathway
Cell cycle pathway
TGF-beta signaling pathway pathway
INOH
PID BIOCARTA
Mets affect on macrophage differentiation [Biocarta view]
PID NCI
Regulation of retinoblastoma protein
E2F transcription factor network
Cross-References
SwissProt
TrEMBL F1MBE6
UniProt Splice Variant
Entrez Gene 525428
UniGene Bt.4316
RefSeq NM_001075873 XM_005218614
HUGO HGNC:3118
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02046679
GenPept
RNA Seq Atlas 525428
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

(Move your mouse over the image to view a more detailed version)