Bos taurus Gene: BT.98842
Summary
InnateDB Gene IDBG-633641.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.98842
Gene Name DNA mismatch repair protein Msh6
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001424
Encoded Proteins
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116062:
This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer. [provided by RefSeq, Jul 2008]
This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:29968150-29989441
Strand Forward strand
Band
Transcripts
ENSBTAT00000001867 ENSBTAP00000001867
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
Predicted by orthology
Total 53 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0000400 four-way junction DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0030983 mismatched DNA binding
GO:0032137 guanine/thymine mispair binding
GO:0032142 single guanine insertion binding
GO:0032143 single thymine insertion binding
GO:0032357 oxidized purine DNA binding
GO:0032405 MutLalpha complex binding
GO:0035064 methylated histone binding
GO:0043531 ADP binding
Biological Process
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0008340 determination of adult lifespan
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009411 response to UV
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0045190 isotype switching
GO:0045910 negative regulation of DNA recombination
GO:0051096 positive regulation of helicase activity
GO:0097193 intrinsic apoptotic signaling pathway
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0032301 MutSalpha complex
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
Mismatch Repair pathway
DNA Repair pathway
DNA Repair pathway
Mismatch Repair pathway
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
KEGG
Mismatch repair pathway
Pathways in cancer pathway
Colorectal cancer pathway
Mismatch repair pathway
Pathways in cancer pathway
Colorectal cancer pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL E1B9Q4
UniProt Splice Variant
Entrez Gene 540526
UniGene
RefSeq NM_001192737 XM_005212664
HUGO HGNC:7329
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02030744
GenPept
RNA Seq Atlas 540526
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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