Homo sapiens Gene: IL12A
Summary
InnateDB Gene IDBG-63368.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL12A
Gene Name interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
Synonyms CLMF; IL-12A; NFSK; NKSF1; P35;
Species Homo sapiens
Ensembl Gene ENSG00000168811
Encoded Proteins
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IL12, consisting of IL12A and IL12B subunits, initiates local anti-tumour immunity by stimulating lymphoid tissue-inducer (LTi) cells bearing the natural cytotoxicity receptor NCR1 (NKp46).
IL12, consisting of IL12A and IL12B subunits, induces IL2RA to form high-affinity IL2 receptors on natural killer cells in response to mouse cytomegalovirus infection. (Demonstrated in mouse)
Macrophages cultured with bile acids produce lower levels of IL12 and display an anti-inflammatory phenotype characterized by an increased ratio of IL10 to IL12
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Il12, consisting of Il12a and Il12b subunits, induces Il2ra to form high-affinity Il2 receptors on natural killer cells in response to mouse cytomegalovirus infection.
Entrez Gene
Summary This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:159988750-159996019
Strand Forward strand
Band q25.33
Transcripts
ENST00000305579 ENSP00000303231
ENST00000480088
ENST00000468862
ENST00000496308
ENST00000480787 ENSP00000420184
ENST00000466512 ENSP00000419046
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 11 [view]
Protein-DNA 18 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005143 interleukin-12 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0042163 interleukin-12 beta subunit binding
GO:0045513 interleukin-27 binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0006955 immune response
GO:0007050 cell cycle arrest
GO:0009615 response to virus
GO:0010224 response to UV-B
GO:0016477 cell migration
GO:0032496 response to lipopolysaccharide
GO:0032700 negative regulation of interleukin-17 production
GO:0032729 positive regulation of interferon-gamma production
GO:0032816 positive regulation of natural killer cell activation
GO:0032946 positive regulation of mononuclear cell proliferation
GO:0034393 positive regulation of smooth muscle cell apoptotic process
GO:0042102 positive regulation of T cell proliferation
GO:0042520 positive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042832 defense response to protozoan
GO:0045087 innate immune response (InnateDB)
GO:0045582 positive regulation of T cell differentiation
GO:0045785 positive regulation of cell adhesion
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050830 defense response to Gram-positive bacterium
GO:0051135 positive regulation of NK T cell activation
GO:0097191 extrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0043514 interleukin-12 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Toll-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Type I diabetes mellitus pathway
Leishmaniasis pathway
Chagas disease (American trypanosomiasis) pathway
African trypanosomiasis pathway
Malaria pathway
Toxoplasmosis pathway
Amoebiasis pathway
Allograft rejection pathway
INOH
GPCR signaling pathway
JAK STAT pathway and regulation pathway
IL-12 signaling pathway
PID BIOCARTA
No2-dependent il-12 pathway in nk cells [Biocarta view]
Il12 and stat4 dependent signaling pathway in th1 development [Biocarta view]
PID NCI
IL27-mediated signaling events
IL12-mediated signaling events
Cross-References
SwissProt P29459
TrEMBL E7ENE1 E9PGR3 O60595 Q7LDP2
UniProt Splice Variant
Entrez Gene 3592
UniGene Hs.673
RefSeq NM_000882 XM_005247435
HUGO HGNC:5969
OMIM 161560
CCDS CCDS3187
HPRD
IMGT
EMBL AC010370 AF050083 AF101062 AF180562 AF404773 BC104982 BC104984 CH471052 M65271 M65291
GenPept AAA35694 AAA59937 AAC05211 AAD16432 AAD56385 AAI04983 AAI04985 AAK84425 EAW78656
RNA Seq Atlas 3592