Version 5.4
Bos taurus Gene: IGFBP1
Summary
InnateDB Gene IDBG-634003.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGFBP1
Gene Name Insulin-like growth factor-binding protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000046768
Encoded Proteins
IDBP-685752
Insulin-like growth factor-binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146678:
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:76720883-76725301
Strand Reverse strand
Band
Transcripts
ENSBTAT00000064194 ENSBTAP00000055280
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005520 insulin-like growth factor binding
GO:0019838 growth factor binding
Biological Process
GO:0001558 regulation of cell growth
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000146678
View Gene Order
ENSMUSG00000020429
View Gene Order
Pathways
NETPATH
REACTOME
REACT_207291
PERK regulates gene expression pathway
REACT_206584
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_204438
ATF4 activates genes pathway
REACT_213782
Metabolism of proteins pathway
REACT_226614
Unfolded Protein Response (UPR) pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18355
ATF4 activates genes pathway
REACT_18277
PERK regulates gene expression pathway
REACT_15428
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
REACT_239697
Unfolded Protein Response (UPR) pathway
REACT_247926
Metabolism of proteins pathway
REACT_235886
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_243361
PERK regulates gene expression pathway
REACT_90370
ATF4 activates genes pathway
KEGG
INOH
INOH website
IGF1 signaling pathway pathway
PID NCI
hnf3bpathway
FOXA2 and FOXA3 transcription factor networks
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt P24591
TrEMBL
UniProt Splice Variant
Entrez Gene 282259
UniGene Bt.190
RefSeq NM_174554
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC111197 X54979
GenPept AAI11198 CAA38723
RNA Seq Atlas 282259
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

(Move your mouse over the image to view a more detailed version)

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca