|Bos taurus Gene: CCM2
|2014-10-13 [Report errors or provide feedback]
cerebral cavernous malformation 2
|Stemformatics EHFPI ImmGen
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136280:
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
|Number of Interactions
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
|Pathway Predictions based on Human Orthology Data
Regulation of p38-alpha and p38-beta
p38 MAPK signaling pathway
|UniProt Splice Variant
|NM_001193211 XM_005205580 XM_005205582 XM_005205583 XM_005205584 XM_005205585
|RNA Seq Atlas