InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.105181

Summary

InnateDB Gene

IDBG-634110.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.105181

Gene Name

nuclear factor of activated T-cells, cytoplasmic 3

Synonyms

NFATx

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004368

Encoded Proteins

IDBP-685862

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21726630

[Homo sapiens] NFATC3 is a transcription factor required for the regulation of the Toll-like receptor-activated innate inflammatory response in monocytes/macrophages. (Demonstrated in murine model)

PMID 21726630

[Mus musculus] Nfatc3 is a transcription factor required for the regulation of the Toll-like receptor-activated innate inflammatory response in monocytes/macrophages.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072736:
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:35640709-35732176

Strand

Forward strand

Band

Transcripts

ENSBTAT00000005727

ENSBTAP00000005727

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0006355	regulation of transcription, DNA-templated
GO:0007507	heart development
GO:0045333	cellular respiration
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051145	smooth muscle cell differentiation
GO:0055001	muscle cell development
GO:0071277	cellular response to calcium ion
GO:0071285	cellular response to lithium ion