Version 5.4
Bos taurus Gene: NFAT5
Summary
InnateDB Gene IDBG-634541.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFAT5
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013412
Encoded Proteins
IDBP-686362
nuclear factor of activated T-cells 5, tonicity-responsive
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20685965
[Homo sapiens] NFAT5 is a transcription factor that is upregulated by hypertonicity. Activated NFAT5 enhances LPS-mediated NFkB activity by complexing with NFkB and kB elements in downstream genes. (Demonstrated in murine model)
PMID 22496647
[Homo sapiens] NFAT5 expression is strongly induced by Mycobacterium tuberculosis, and plays an essential role in stimulating HIV replication in co-infected macrophages.
PMID 20685965
[Mus musculus] Nfat5 is a transcription factor that is upregulated by hypertonicity. Activated Nfat5 enhances LPS-mediated NFkB activity by complexing with NFkB and kB elements in downstream genes.
PMID 22496647
[Mus musculus] Nfat5 expression is strongly induced by Mycobacterium tuberculosis, and plays an essential role in stimulating HIV replication in co-infected macrophages. (Demonstrated in human)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102908:
The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:36847730-36898690
Strand Forward strand
Band
Transcripts
ENSBTAT00000017847 ENSBTAP00000017847
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0001816 cytokine production
GO:0006355 regulation of transcription, DNA-templated
GO:0010628 positive regulation of gene expression
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0070884 regulation of calcineurin-NFAT signaling cascade
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000102908
View Gene Order
ENSMUSG00000003847
View Gene Order
Cross-References
SwissProt
TrEMBL F1MAZ9
UniProt Splice Variant
Entrez Gene 538523
UniGene
RefSeq XM_002694839 XM_003583392 XM_003587226 XM_005218872 XM_877976
HUGO HGNC:7774
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02046708
GenPept
RNA Seq Atlas 538523

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca