Version 5.4
Bos taurus Gene: EIF4A1
Summary
InnateDB Gene IDBG-635028.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4A1
Gene Name Eukaryotic initiation factor 4A-I
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000132
Encoded Proteins
IDBP-686827
Eukaryotic initiation factor 4A-I
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161960:
Gene Information
Type Protein coding
Genomic Location Chromosome 19:27915413-27921421
Strand Forward strand
Band
Transcripts
ENSBTAT00000000144 ENSBTAP00000000144
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.
Predicted by orthology
Total 63 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003743 translation initiation factor activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0016787 hydrolase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006412 translation
GO:0006413 translational initiation
Cellular Component
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000161960
View Gene Order
ENSMUSG00000059796
View Gene Order
Pathways
NETPATH
REACTOME
REACT_224454
Deadenylation of mRNA pathway
REACT_215264
ISG15 antiviral mechanism pathway
REACT_246268
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_213612
Cytokine Signaling in Immune system pathway
REACT_226022
Gene Expression pathway
REACT_218564
Eukaryotic Translation Initiation pathway
REACT_225918
Cap-dependent Translation Initiation pathway
REACT_213138
Immune System pathway
REACT_224319
Antiviral mechanism by IFN-stimulated genes pathway
REACT_209048
Translation pathway
REACT_202903
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_213782
Metabolism of proteins pathway
REACT_225103
Interferon Signaling pathway
REACT_220444
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_224343
Translation initiation complex formation pathway
REACT_203426
Deadenylation-dependent mRNA decay pathway
REACT_222420
Ribosomal scanning and start codon recognition pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_115831
ISG15 antiviral mechanism pathway
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_20514
Deadenylation of mRNA pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_1014
Translation pathway
REACT_25229
Interferon Signaling pathway
REACT_17015
Metabolism of proteins pathway
REACT_6900
Immune System pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
REACT_255163
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_244119
Deadenylation of mRNA pathway
REACT_254308
Translation pathway
REACT_198535
Antiviral mechanism by IFN-stimulated genes pathway
REACT_198533
ISG15 antiviral mechanism pathway
REACT_230745
Immune System pathway
REACT_256488
Translation initiation complex formation pathway
REACT_247926
Metabolism of proteins pathway
REACT_229570
Cap-dependent Translation Initiation pathway
REACT_262064
Eukaryotic Translation Initiation pathway
REACT_198666
Interferon Signaling pathway
REACT_233572
Gene Expression pathway
REACT_259469
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_236458
Ribosomal scanning and start codon recognition pathway
REACT_262078
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_235784
Deadenylation-dependent mRNA decay pathway
KEGG
hsa03013
RNA transport pathway
mmu03013
RNA transport pathway
INOH
INOH website
Insulin receptor signaling pathway
INOH website
Insulin receptor signaling pathway
PID NCI
mtor_4pathway
mTOR signaling pathway
myc_activpathway
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt Q3SZ54
TrEMBL
UniProt Splice Variant
Entrez Gene 504958
UniGene Bt.14169 Bt.65964
RefSeq NM_001034228
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103130
GenPept AAI03131
RNA Seq Atlas 504958

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca