InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DDX20

Summary

InnateDB Gene

IDBG-635035.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX20

Gene Name

probable ATP-dependent RNA helicase DDX20

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018717

Encoded Proteins

IDBP-686838

probable ATP-dependent RNA helicase DDX20

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000064703:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:31693938-31704445

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000024914

ENSBTAP00000024914

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0016787	hydrolase activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000387	spliceosomal snRNP assembly
GO:0006200	ATP catabolic process
GO:0008152	metabolic process
GO:0043065	positive regulation of apoptotic process
GO:0048477	oogenesis
GO:0050810	regulation of steroid biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0017053	transcriptional repressor complex
GO:0032797	SMN complex
GO:0034719	SMN-Sm protein complex