Homo sapiens Gene: MCM3AP
Summary
InnateDB Gene IDBG-6351.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCM3AP
Gene Name minichromosome maintenance complex component 3 associated protein
Synonyms GANP; MAP80; SAC3;
Species Homo sapiens
Ensembl Gene ENSG00000160294
Encoded Proteins
minichromosome maintenance complex component 3 associated protein
minichromosome maintenance complex component 3 associated protein
minichromosome maintenance complex component 3 associated protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. [provided by RefSeq, Jul 2008]
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:46235126-46286297
Strand Reverse strand
Band q22.3
Transcripts
ENST00000291688 ENSP00000291688
ENST00000397708 ENSP00000380820
ENST00000426537 ENSP00000408934
ENST00000486937
ENST00000496607
ENST00000467026
ENST00000481113
ENST00000494755
ENST00000479557
ENST00000495475
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0002376 immune system process
GO:0006260 DNA replication
GO:0006606 protein import into nucleus
GO:0051028 mRNA transport
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL N0GVG8
UniProt Splice Variant
Entrez Gene 8888
UniGene Hs.389037 Hs.592438 Hs.678090
RefSeq NM_003906 XM_006724065 XM_005261206 XM_006724064 XM_005261205 XM_005261204 XM_005261203
HUGO HGNC:6946
OMIM 603294
CCDS CCDS13734
HPRD 04483
IMGT
EMBL HF584748
GenPept CCQ44045
RNA Seq Atlas 8888