Version 5.4
Bos taurus Gene: UBA2
Summary
InnateDB Gene IDBG-635400.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBA2
Gene Name SUMO-activating enzyme subunit 2
Synonyms SAE2
Species Bos taurus
Ensembl Gene ENSBTAG00000002573
Encoded Proteins
IDBP-687241
SUMO-activating enzyme subunit 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126261:
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:45036893-45067601
Strand Forward strand
Band
Transcripts
ENSBTAT00000003333 ENSBTAP00000003333
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.
Predicted by orthology
Total 49 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0008641 small protein activating enzyme activity
GO:0016874 ligase activity
GO:0019948 SUMO activating enzyme activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006464 cellular protein modification process
GO:0016925 protein sumoylation
GO:0019950 SMT3-dependent protein catabolic process
Cellular Component
GO:0005829 cytosol
GO:0031510 SUMO activating enzyme complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000126261
View Gene Order
ENSMUSG00000052997
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22161
Post-translational protein modification pathway
REACT_163793
Processing and activation of SUMO pathway
REACT_17015
Metabolism of proteins pathway
REACT_163646
SUMO is transferred from E1 to E2 (UBE2I, UBC9) pathway
REACT_163812
SUMO is conjugated to E1 (UBA2:SAE1) pathway
REACT_163823
SUMOylation pathway
REACT_196647
SUMO is conjugated to E1 (UBA2:SAE1) pathway
REACT_196652
SUMOylation pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_223195
SUMO is transferred from E1 to E2 (UBE2I, UBC9) pathway
REACT_196651
Processing and activation of SUMO pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
mmu04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A4FV12
UniProt Splice Variant
Entrez Gene 507005
UniGene Bt.13185
RefSeq NM_001083381
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123590 DAAA02046904
GenPept AAI23591
RNA Seq Atlas 507005

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca