InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TPMT

Summary

InnateDB Gene

IDBG-635880.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TPMT

Gene Name

Thiopurine S-methyltransferase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019300

Encoded Proteins

IDBP-687755

Thiopurine S-methyltransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137364:
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q. [provided by RefSeq, Jul 2008]
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:39209390-39232415

Strand

Forward strand

Band

Transcripts

ENSBTAT00000025698

ENSBTAP00000025698

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008119	thiopurine S-methyltransferase activity
GO:0008168	methyltransferase activity
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
GO:0016740	transferase activity