Homo sapiens Gene: EIF2B1
Summary
InnateDB Gene IDBG-63590.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF2B1
Gene Name eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
Synonyms EIF2B; EIF2BA;
Species Homo sapiens
Ensembl Gene ENSG00000111361
Encoded Proteins
eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:123620406-123633766
Strand Reverse strand
Band q24.31
Transcripts
ENST00000424014 ENSP00000416250
ENST00000452159
ENST00000539951 ENSP00000438060
ENST00000534960 ENSP00000443172
ENST00000537073 ENSP00000444183
ENST00000543940
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
GO:0030234 enzyme regulator activity
Biological Process
GO:0006412 translation
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0006446 regulation of translational initiation
GO:0009408 response to heat
GO:0009749 response to glucose
GO:0010467 gene expression
GO:0014003 oligodendrocyte development
GO:0032057 negative regulation of translational initiation in response to stress
GO:0043434 response to peptide hormone
GO:0043547 positive regulation of GTPase activity
GO:0044237 cellular metabolic process
GO:0044267 cellular protein metabolic process
GO:0050790 regulation of catalytic activity
GO:0051716 cellular response to stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005851 eukaryotic translation initiation factor 2B complex
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Eukaryotic Translation Initiation pathway
Translation pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
Recycling of eIF2:GDP pathway
Gene Expression pathway
KEGG
RNA transport pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.599964 Hs.623880 Hs.741273
RefSeq NM_001414
HUGO
OMIM
CCDS CCDS31924
HPRD 09458
IMGT
EMBL
GenPept
RNA Seq Atlas