Version 5.4
Bos taurus Gene: JARID2
Summary
InnateDB Gene IDBG-636025.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol JARID2
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012938
Encoded Proteins
IDBP-687912
jumonji, AT rich interactive domain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000008083:
This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:41165798-41302731
Strand Reverse strand
Band
Transcripts
ENSBTAT00000017189 ENSBTAP00000017189
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001889 liver development
GO:0008285 negative regulation of cell proliferation
GO:0031061 negative regulation of histone methylation
GO:0042127 regulation of cell proliferation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048863 stem cell differentiation
GO:0051574 positive regulation of histone H3-K9 methylation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0035097 histone methyltransferase complex
GO:0035098 ESC/E(Z) complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000008083
View Gene Order
ENSMUSG00000038518
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_200808
PRC2 methylates histones and DNA pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_71
Gene Expression pathway
REACT_222475
PRC2 methylates histones and DNA pathway
REACT_205737
Epigenetic regulation of gene expression pathway
REACT_233572
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MH56
UniProt Splice Variant
Entrez Gene 528253
UniGene Bt.103500 Bt.111637 Bt.45693
RefSeq XM_002697579 XM_003583926 XM_005196693 XM_005196695 XM_005196697 XM_005223836 XM_005223838
HUGO HGNC:6196
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02055659 DAAA02055660 DAAA02055661 DAAA02055662
GenPept
RNA Seq Atlas 528253

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca