Bos taurus Gene: XBP1
Summary
InnateDB Gene IDBG-636048.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XBP1
Gene Name X-box-binding protein 1
Synonyms XBPP1;
Species Bos taurus
Ensembl Gene ENSBTAG00000005970
Encoded Proteins
X-box-binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] XBP1 transcription factor regulates innate immune responses in macrophages via TLR2 activation and its deficiency results in a much greater bacterial burden in mice infected with the TLR2-activating human intracellular pathogen Francisella tularensis.
[Homo sapiens] XBP1/ERN1 (IRE1)-mediated signalling plays roles in the coordination of metabolic and immune responses by acting as a regulatory hub, linking endoplasmic reticulum homeostasis with innate immunity and metabolism.
[Homo sapiens] XBP1 interacts with EP300 to augment IFN-beta induction via a cis-acting enhancer in macrophages under endoplasmic reticulum stress.
[Homo sapiens] XBP1 is an important regulator in ER stress response and may function collaboratively with innate immunity to maintain cellular homeostasis. XBP1 is essential in poly(I:C)-signalling and ER stress-amplified IFNB production in dendritic cells, and the over-expression of XBP1 synergistically augments the poly(I:C)-induced inflammatory response. (Demonstrated in murine model)
[Mus musculus] Xbp1 transcription factor regulates innate immune responses in macrophages via Tlr2 activation and its deficiency results in a much greater bacterial burden in mice infected with the Tlr2-activating human intracellular pathogen Francisella tularensis.
[Mus musculus] Xbp1 is an important regulator in ER stress response and may function collaboratively with innate immunity to maintain cellular homeostasis. Xbp1 is essential in poly(I:C)-signalling and ER stress-amplified IFNB production in dendritic cells, and the over-expression of Xbp1 synergistically augments the poly(I:C)-induced inflammatory response.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100219:
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:70344599-70349566
Strand Reverse strand
Band
Transcripts
ENSBTAT00000007835 ENSBTAP00000007835
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001085 RNA polymerase II transcription factor binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0002070 epithelial cell maturation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0031017 exocrine pancreas development
GO:0042593 glucose homeostasis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060691 epithelial cell maturation involved in salivary gland development
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
ATF6-alpha activates chaperone genes pathway
IRE1alpha activates chaperones pathway
Metabolism of proteins pathway
XBP1(S) activates chaperone genes pathway
Unfolded Protein Response (UPR) pathway
ATF6-alpha activates chaperones pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
ATF6-alpha activates chaperone genes pathway
Unfolded Protein Response (UPR) pathway
Metabolism of proteins pathway
IRE1alpha activates chaperones pathway
ATF6-alpha activates chaperones pathway
XBP1(S) activates chaperone genes pathway
KEGG
Protein processing in endoplasmic reticulum pathway
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
PID NCI
Validated nuclear estrogen receptor alpha network
FOXA1 transcription factor network
Cross-References
SwissProt Q3SZZ2
TrEMBL
UniProt Splice Variant
Entrez Gene 541236
UniGene Bt.111415 Bt.89117
RefSeq NM_001034727
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102639
GenPept AAI02640
RNA Seq Atlas 541236