Version 5.4
Bos taurus Gene: AGL
Summary
InnateDB Gene IDBG-636247.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGL
Gene Name glycogen debranching enzyme
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006491
Encoded Proteins
IDBP-688164
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162688:
This gene encodes the glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. Mutations in this gene are associated with glycogen storage disease although a wide range of enzymatic and clinical variability occurs which may be due to tissue-specific alternative splicing. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:43504601-43585149
Strand Reverse strand
Band
Transcripts
ENSBTAT00000008518 ENSBTAP00000008518
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004133 glycogen debranching enzyme activity
GO:0004134 4-alpha-glucanotransferase activity
GO:0004135 amylo-alpha-1,6-glucosidase activity
GO:0005515 protein binding
GO:0030247 polysaccharide binding
GO:0031593 polyubiquitin binding
GO:0043169 cation binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005977 glycogen metabolic process
GO:0005978 glycogen biosynthetic process
GO:0005980 glycogen catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016234 inclusion body
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000162688
View Gene Order
ENSMUSG00000033400
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1008
Glycogen breakdown (glycogenolysis) pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa00500
Starch and sucrose metabolism pathway
mmu00500
Starch and sucrose metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.24918
RefSeq NM_001192471 XM_005204113 XM_005204114 XM_005204115
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca