Homo sapiens Gene: COX4I2
Summary
InnateDB Gene IDBG-63641.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COX4I2
Gene Name cytochrome c oxidase subunit IV isoform 2 (lung)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000131055
Encoded Proteins
cytochrome c oxidase subunit IV isoform 2 (lung)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:31637888-31645006
Strand Forward strand
Band q11.21
Transcripts
ENST00000376075 ENSP00000365243
ENST00000490030
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004129 cytochrome-c oxidase activity
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0045333 cellular respiration
GO:0055114 oxidation-reduction process
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005751 mitochondrial respiratory chain complex IV
GO:0031966 mitochondrial membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Oxidative phosphorylation pathway
Cardiac muscle contraction pathway
Alzheimer's disease pathway
Parkinson's disease pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_032609
HUGO
OMIM
CCDS CCDS13187
HPRD 12143
IMGT
EMBL
GenPept
RNA Seq Atlas