InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GCKR

Summary

InnateDB Gene

IDBG-636508.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCKR

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000031302

Encoded Proteins

IDBP-688438

glucokinase (hexokinase 4) regulator

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000084734:
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:72154947-72176344

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000044354

ENSBTAP00000041859

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0070095	fructose-6-phosphate binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0001678	cellular glucose homeostasis
GO:0009750	response to fructose
GO:0033132	negative regulation of glucokinase activity
GO:0033133	positive regulation of glucokinase activity
GO:0046415	urate metabolic process
GO:0070328	triglyceride homeostasis