Bos taurus Gene: IL2RA
Summary
InnateDB Gene IDBG-637067.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL2RA
Gene Name interleukin-2 receptor subunit alpha precursor
Synonyms CD25;
Species Bos taurus
Ensembl Gene ENSBTAG00000020892
Encoded Proteins
interleukin-2 receptor subunit alpha precursor
interleukin-2 receptor subunit alpha precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134460:
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:17540961-17586321
Strand Forward strand
Band
Transcripts
ENSBTAT00000027834 ENSBTAP00000027834
ENSBTAT00000054113 ENSBTAP00000051522
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004911 interleukin-2 receptor activity
GO:0005515 protein binding
GO:0019976 interleukin-2 binding
Biological Process
GO:0006924 activation-induced cell death of T cells
GO:0007219 Notch signaling pathway
GO:0042104 positive regulation of activated T cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0043029 T cell homeostasis
GO:0046013 regulation of T cell homeostatic proliferation
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050728 negative regulation of inflammatory response
Cellular Component
GO:0009897 external side of plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathway Predictions based on Human Orthology Data
NETPATH
IL2 pathway
REACTOME
Interleukin-3, 5 and GM-CSF signaling pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Immune System pathway
GPVI-mediated activation cascade pathway
Interleukin-2 signaling pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
G beta:gamma signalling through PI3Kgamma pathway
Hemostasis pathway
GPCR downstream signaling pathway
Hemostasis pathway
Signaling by GPCR pathway
Interleukin-2 signaling pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
GPVI-mediated activation cascade pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
G-protein beta:gamma signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signal Transduction pathway
G beta:gamma signalling through PI3Kgamma pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Endocytosis pathway
Jak-STAT signaling pathway pathway
Hematopoietic cell lineage pathway
Cytokine-cytokine receptor interaction pathway
Endocytosis pathway
Jak-STAT signaling pathway pathway
Hematopoietic cell lineage pathway
INOH
JAK STAT pathway and regulation pathway
IL-2 signaling pathway
JAK STAT pathway and regulation pathway
IL-2 signaling pathway
PID BIOCARTA
Il 2 signaling pathway [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
PID NCI
Calcium signaling in the CD4+ TCR pathway
IL2-mediated signaling events
Downstream signaling in na´ve CD8+ T cells
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
IL12 signaling mediated by STAT4
SHP2 signaling
IL2 signaling events mediated by STAT5
IL2 signaling events mediated by PI3K
Cross-References
SwissProt
TrEMBL A2VE30
UniProt Splice Variant
Entrez Gene 281861
UniGene Bt.3941
RefSeq NM_174358 XM_005214133
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133546 DAAA02035345
GenPept AAI33547
RNA Seq Atlas 281861
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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