Bos taurus Gene: PSMC3
Summary
InnateDB Gene IDBG-637440.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSMC3
Gene Name 26S protease regulatory subunit 6A
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021744
Encoded Proteins
PSMC3 protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165916:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:78452426-78458542
Strand Reverse strand
Band
Transcripts
ENSBTAT00000028983 ENSBTAP00000028983
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 93 interaction(s) predicted by orthology.
Predicted by orthology
Total 93 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0009378 four-way junction helicase activity
GO:0016787 hydrolase activity
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0001824 blastocyst development
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0030163 protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0022624 proteasome accessory complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
REACTOME
DNA Replication pathway
PCP/CE pathway pathway
truncated APC mutants destabilize the destruction complex pathway
p53-Dependent G1/S DNA damage checkpoint pathway
p53-Independent G1/S DNA damage checkpoint pathway
Processing-defective Hh variants abrogate ligand secretion pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
Signaling by Hedgehog pathway
AMER1 mutants destabilize the destruction complex pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Synthesis of DNA pathway
Signaling by WNT in cancer pathway
APC/C-mediated degradation of cell cycle proteins pathway
SCF-beta-TrCP mediated degradation of Emi1 pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
beta-catenin independent WNT signaling pathway
AXIN missense mutants destabilize the destruction complex pathway
Vif-mediated degradation of APOBEC3G pathway
Regulation of mitotic cell cycle pathway
APC/C:Cdc20 mediated degradation of Securin pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Signaling by Wnt pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
Regulation of activated PAK-2p34 by proteasome mediated degradation pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Stabilization of p53 pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of GLI2 by the proteasome pathway
degradation of DVL pathway
GLI3 is processed to GLI3R by the proteasome pathway
Autodegradation of the E3 ubiquitin ligase COP1 pathway
ER-Phagosome pathway pathway
Degradation of beta-catenin by the destruction complex pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Degradation of GLI1 by the proteasome pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Apoptosis pathway
Signal Transduction pathway
Separation of Sister Chromatids pathway
Hedgehog 'off' state pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
Hh ligand biogenesis disease pathway
Ubiquitin-dependent degradation of Cyclin D pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Cell Cycle pathway
Antigen processing-Cross presentation pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
Activation of NF-kappaB in B cells pathway
Adaptive Immune System pathway
Metabolism of amino acids and derivatives pathway
Removal of licensing factors from origins pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Regulation of ornithine decarboxylase (ODC) pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
p53-Dependent G1 DNA Damage Response pathway
truncations of AMER1 destabilize the destruction complex pathway
M Phase pathway
Cyclin E associated events during G1/S transition pathway
Hedgehog ligand biogenesis pathway
Mitotic Anaphase pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
Switching of origins to a post-replicative state pathway
Asymmetric localization of PCP proteins pathway
Ubiquitin-dependent degradation of Cyclin D1 pathway
M/G1 Transition pathway
degradation of AXIN pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Cross-presentation of soluble exogenous antigens (endosomes) pathway
Orc1 removal from chromatin pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
HIV Infection pathway
Class I MHC mediated antigen processing & presentation pathway
CDT1 association with the CDC6:ORC:origin complex pathway
p53-Independent DNA Damage Response pathway
G1/S DNA Damage Checkpoints pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Metabolism pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Host Interactions of HIV factors pathway
Regulation of DNA replication pathway
Signaling by the B Cell Receptor (BCR) pathway
CDK-mediated phosphorylation and removal of Cdc6 pathway
Vpu mediated degradation of CD4 pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Regulation of Apoptosis pathway
Gene Expression pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
Assembly of the pre-replicative complex pathway
Cell Cycle Checkpoints pathway
Mitotic Metaphase and Anaphase pathway
p53-Independent G1/S DNA damage checkpoint pathway
Autodegradation of the E3 ubiquitin ligase COP1 pathway
Apoptosis pathway
Signaling by the B Cell Receptor (BCR) pathway
Cell Cycle, Mitotic pathway
Class I MHC mediated antigen processing & presentation pathway
Disease pathway
Synthesis of DNA pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Ubiquitin-dependent degradation of Cyclin D1 pathway
Signaling by Wnt pathway
CDT1 association with the CDC6:ORC:origin complex pathway
Separation of Sister Chromatids pathway
Hedgehog 'off' state pathway
DNA Replication pathway
Signaling by WNT in cancer pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Switching of origins to a post-replicative state pathway
degradation of DVL pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Degradation of beta-catenin by the destruction complex pathway
beta-catenin independent WNT signaling pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
p53-Independent DNA Damage Response pathway
p53-Dependent G1 DNA Damage Response pathway
p53-Dependent G1/S DNA damage checkpoint pathway
CDK-mediated phosphorylation and removal of Cdc6 pathway
AMER1 mutants destabilize the destruction complex pathway
Cell Cycle pathway
Stabilization of p53 pathway
Metabolism pathway
APC/C-mediated degradation of cell cycle proteins pathway
Immune System pathway
M Phase pathway
Cell Cycle Checkpoints pathway
SCF-beta-TrCP mediated degradation of Emi1 pathway
Hedgehog ligand biogenesis pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
ER-Phagosome pathway pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Processing-defective Hh variants abrogate ligand secretion pathway
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
APC truncation mutants have impaired AXIN binding pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Cross-presentation of soluble exogenous antigens (endosomes) pathway
Regulation of DNA replication pathway
Metabolism of amino acids and derivatives pathway
Orc1 removal from chromatin pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
M/G1 Transition pathway
PCP/CE pathway pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Regulation of Apoptosis pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Activation of NF-kappaB in B cells pathway
Degradation of GLI2 by the proteasome pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Regulation of mitotic cell cycle pathway
APC/C:Cdc20 mediated degradation of Securin pathway
G1/S DNA Damage Checkpoints pathway
Degradation of GLI1 by the proteasome pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Hh ligand biogenesis disease pathway
AXIN missense mutants destabilize the destruction complex pathway
TCF dependent signaling in response to WNT pathway
GLI3 is processed to GLI3R by the proteasome pathway
Mitotic Metaphase and Anaphase pathway
G1/S Transition pathway
Removal of licensing factors from origins pathway
APC truncation mutants are not K63 polyubiquitinated pathway
Regulation of ornithine decarboxylase (ODC) pathway
Antigen processing-Cross presentation pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
Mitotic G1-G1/S phases pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
TCF7L2 mutants don't bind CTBP pathway
Regulation of activated PAK-2p34 by proteasome mediated degradation pathway
Gene Expression pathway
Adaptive Immune System pathway
truncations of AMER1 destabilize the destruction complex pathway
Ubiquitin-dependent degradation of Cyclin D pathway
Signaling by Hedgehog pathway
degradation of AXIN pathway
Asymmetric localization of PCP proteins pathway
Cyclin E associated events during G1/S transition pathway
Signal Transduction pathway
truncated APC mutants destabilize the destruction complex pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
DNA Replication Pre-Initiation pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
Mitotic Anaphase pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Assembly of the pre-replicative complex pathway
S Phase pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
Proteasome pathway
Proteasome pathway
INOH
TGF-beta signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F1MWE0 Q1JP95 Q3SZ81
UniProt Splice Variant
Entrez Gene 508448
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103063 BT025458 DAAA02041602
GenPept AAI03064 ABF57414
RNA Seq Atlas 508448
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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