Version 5.4
Homo sapiens Gene: CREB3
Summary
InnateDB Gene IDBG-63795.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CREB3
Gene Name cAMP responsive element binding protein 3
Synonyms LUMAN; LZIP
Species Homo sapiens
Ensembl Gene ENSG00000107175
Encoded Proteins
IDBP-63799
cAMP responsive element binding protein 3
IDBP-809098
cAMP responsive element binding protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:35732320-35737007
Strand Forward strand
Band p13.3
Transcripts
ENST00000353704 ENSP00000342136
ENST00000486056
ENST00000613913 ENSP00000484327
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 141 experimentally validated interaction(s) in this database.
Experimentally validated
Total 141 [view]
Protein-Protein 140 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008140 cAMP response element binding protein binding
GO:0031726 CCR1 chemokine receptor binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0001558 regulation of cell growth
GO:0002230 positive regulation of defense response to virus by host
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006935 chemotaxis
GO:0006986 response to unfolded protein
GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
GO:0016032 viral process
GO:0019043 establishment of viral latency
GO:0019046 release from viral latency
GO:0030335 positive regulation of cell migration
GO:0034976 response to endoplasmic reticulum stress
GO:0042127 regulation of cell proliferation
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0045786 negative regulation of cell cycle
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050930 induction of positive chemotaxis
GO:0051928 positive regulation of calcium ion transport
GO:0090026 positive regulation of monocyte chemotaxis
GO:0090045 positive regulation of deacetylase activity
GO:2000326 negative regulation of ligand-dependent nuclear receptor transcription coactivator activity
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016604 nuclear body
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028466
View Gene Order
ENSBTAG00000011429
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05215
Prostate cancer pathway
hsa04916
Melanogenesis pathway
hsa05016
Huntington's disease pathway
hsa04962
Vasopressin-regulated water reabsorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.522110
RefSeq NM_006368
HUGO
OMIM
CCDS CCDS6588
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca