Bos taurus Gene: PROX1
Summary
InnateDB Gene IDBG-638014.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PROX1
Gene Name prospero homeobox protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010978
Encoded Proteins
prospero homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117707:
The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:71413974-71455068
Strand Reverse strand
Band
Transcripts
ENSBTAT00000014573 ENSBTAP00000014573
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0016922 ligand-dependent nuclear receptor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0050692 DBD domain binding
GO:0050693 LBD domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001709 cell fate determination
GO:0001822 kidney development
GO:0001889 liver development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001945 lymph vessel development
GO:0001946 lymphangiogenesis
GO:0002088 lens development in camera-type eye
GO:0002089 lens morphogenesis in camera-type eye
GO:0002194 hepatocyte cell migration
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007275 multicellular organismal development
GO:0007420 brain development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010468 regulation of gene expression
GO:0010595 positive regulation of endothelial cell migration
GO:0021542 dentate gyrus development
GO:0021707 cerebellar granule cell differentiation
GO:0030240 skeletal muscle thin filament assembly
GO:0030324 lung development
GO:0031016 pancreas development
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045071 negative regulation of viral genome replication
GO:0045446 endothelial cell differentiation
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046619 optic placode formation involved in camera-type eye formation
GO:0048839 inner ear development
GO:0048845 venous blood vessel morphogenesis
GO:0055005 ventricular cardiac myofibril assembly
GO:0055009 atrial cardiac muscle tissue morphogenesis
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060059 embryonic retina morphogenesis in camera-type eye
GO:0060214 endocardium formation
GO:0060298 positive regulation of sarcomere organization
GO:0060412 ventricular septum morphogenesis
GO:0060414 aorta smooth muscle tissue morphogenesis
GO:0060421 positive regulation of heart growth
GO:0060836 lymphatic endothelial cell differentiation
GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment
GO:0070309 lens fiber cell morphogenesis
GO:0070365 hepatocyte differentiation
GO:0070858 negative regulation of bile acid biosynthetic process
GO:0072574 hepatocyte proliferation
GO:0097150 neuronal stem cell maintenance
GO:1901978 positive regulation of cell cycle checkpoint
GO:2000179 positive regulation of neural precursor cell proliferation
GO:2000979 positive regulation of forebrain neuron differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL E1BM20
UniProt Splice Variant
Entrez Gene 515324
UniGene Bt.106201
RefSeq NM_001193232 XM_005217353 XM_005217354 XM_005217355 XM_005217356 XM_005217357 XM_005217358 XM_005217359 XM_005217360
HUGO HGNC:9459
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02043725
GenPept
RNA Seq Atlas 515324
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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