Homo sapiens Gene: CSH1
Summary
InnateDB Gene IDBG-63837.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSH1
Gene Name chorionic somatomammotropin hormone 1 (placental lactogen)
Synonyms CS-1; CSA; CSMT; hCS-1; hCS-A; PL;
Species Homo sapiens
Ensembl Gene ENSG00000136488
Encoded Proteins
chorionic somatomammotropin hormone 1 (placental lactogen)
chorionic somatomammotropin hormone 1 (placental lactogen)
chorionic somatomammotropin hormone 1 (placental lactogen)
chorionic somatomammotropin hormone 1 (placental lactogen)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. This particular family member is expressed in placental villi, although it was originally thought to be a pseudogene. In fact, alternative splicing suggests that the majority of the transcripts would be unable to express a secreted protein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:63894909-63896661
Strand Reverse strand
Band q23.3
Transcripts
ENST00000316193 ENSP00000316416
ENST00000329882 ENSP00000333268
ENST00000453363 ENSP00000402517
ENST00000558284
ENST00000558661
ENST00000610991 ENSP00000478652
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0046872 metal ion binding
Biological Process
Cellular Component
GO:0005576 extracellular region
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Cytokine Signaling in Immune system pathway
Signaling by ERBB4 pathway
Signal Transduction pathway
Prolactin receptor signaling pathway
Immune System pathway
Growth hormone receptor signaling pathway
Nuclear signaling by ERBB4 pathway
KEGG
Neuroactive ligand-receptor interaction pathway
Jak-STAT signaling pathway pathway
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P0DML2
TrEMBL A6NFB4 A8K6C2 B1A4H2 P78451 Q7KZ35
UniProt Splice Variant
Entrez Gene 1442
UniGene
RefSeq NM_001317
HUGO HGNC:2440
OMIM 150200
CCDS CCDS11649
HPRD
IMGT
EMBL AC040958 AC127029 AK291587 BC002717 BC005921 BC020756 BC062775 BT006926 CH471109 EU421714 J00118 J03071 K02401 M25118 V00593
GenPept AAA35721 AAA52115 AAA52551 AAA98621 AAH02717 AAH05921 AAH20756 AAH62775 AAP35572 ABZ88716 ABZ88717 ABZ88718 BAF84276 CAA23840 EAW94235 EAW94236 EAW94237 EAW94241 EAW94243 EAW94254 EAW94257 EAW94259
RNA Seq Atlas 1442