Version 5.4
Homo sapiens Gene: MAP4K4
Summary
InnateDB Gene IDBG-63853.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP4K4
Gene Name mitogen-activated protein kinase kinase kinase kinase 4
Synonyms FLH21957; HEL-S-31; HGK; MEKKK4; NIK
Species Homo sapiens
Ensembl Gene ENSG00000071054
Encoded Proteins
IDBP-63855
mitogen-activated protein kinase kinase kinase kinase 4
IDBP-63857
mitogen-activated protein kinase kinase kinase kinase 4
IDBP-63859
mitogen-activated protein kinase kinase kinase kinase 4
IDBP-63861
mitogen-activated protein kinase kinase kinase kinase 4
IDBP-63863
mitogen-activated protein kinase kinase kinase kinase 4
IDBP-383792
mitogen-activated protein kinase kinase kinase kinase 4
IDBP-383808
mitogen-activated protein kinase kinase kinase kinase 4
IDBP-383810
mitogen-activated protein kinase kinase kinase kinase 4
IDBP-383811
mitogen-activated protein kinase kinase kinase kinase 4
IDBP-383812
mitogen-activated protein kinase kinase kinase kinase 4
IDBP-383813
mitogen-activated protein kinase kinase kinase kinase 4
IDBP-383814
mitogen-activated protein kinase kinase kinase kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:101696850-101894689
Strand Forward strand
Band q11.2
Transcripts
ENST00000324219 ENSP00000313644
ENST00000350878 ENSP00000343658
ENST00000347699 ENSP00000314363
ENST00000350198 ENSP00000281111
ENST00000302217 ENSP00000303600
ENST00000427603 ENSP00000403016
ENST00000425019 ENSP00000392830
ENST00000413150 ENSP00000389752
ENST00000456652 ENSP00000387370
ENST00000417294 ENSP00000409720
ENST00000421882 ENSP00000396066
ENST00000418101 ENSP00000414766
ENST00000496989
ENST00000489490
ENST00000476609
ENST00000477711
ENST00000498066
ENST00000491743
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0010977 negative regulation of neuron projection development
GO:0023014 signal transduction by phosphorylation
GO:0035556 intracellular signal transduction
GO:0046328 regulation of JNK cascade
GO:0050790 regulation of catalytic activity
GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070571 negative regulation of neuron projection regeneration
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026074
View Gene Order
ENSBTAG00000013023
Not yet available
Pathways
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_169274
Cellular Senescence pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
ceramide_pathway
Ceramide signaling pathway
p53downstreampathway
Direct p53 effectors
ephbfwdpathway
EPHB forward signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 9448
UniGene Hs.431550 Hs.701013
RefSeq XM_005264053 XM_005264054 XM_005264055 XM_005264056 NM_001242559 NM_001242560 NM_004834 NM_145686 NM_145687 XM_005264059 XM_005264060 XM_005264069
HUGO HGNC:6866
OMIM 604666
CCDS CCDS56130 CCDS74546
HPRD 05235
IMGT
EMBL
GenPept
RNA Seq Atlas 9448

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca