Version 5.4
Bos taurus Gene: ERCC3
Summary
InnateDB Gene IDBG-639240.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERCC3
Gene Name TFIIH basal transcription factor complex helicase XPB subunit
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020777
Encoded Proteins
IDBP-691385
TFIIH basal transcription factor complex helicase XPB subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163161:
ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:5181037-5211357
Strand Forward strand
Band
Transcripts
ENSBTAT00000027687 ENSBTAP00000027687
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0004386 helicase activity
GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008134 transcription factor binding
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity
GO:0016787 hydrolase activity
GO:0016887 ATPase activity
GO:0043138 3'-5' DNA helicase activity
GO:0047485 protein N-terminus binding
Biological Process
GO:0000717 nucleotide-excision repair, DNA duplex unwinding
GO:0006200 ATP catabolic process
GO:0006265 DNA topological change
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0006979 response to oxidative stress
GO:0008104 protein localization
GO:0009411 response to UV
GO:0009650 UV protection
GO:0033683 nucleotide-excision repair, DNA incision
GO:0035315 hair cell differentiation
GO:0043065 positive regulation of apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:1901990 regulation of mitotic cell cycle phase transition
Cellular Component
GO:0005634 nucleus
GO:0005675 holo TFIIH complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000163161
View Gene Order
ENSMUSG00000024382
View Gene Order
Pathways
NETPATH
REACTOME
REACT_221445
RNA Polymerase I Transcription Termination pathway
REACT_209718
RNA Polymerase II Transcription pathway
REACT_207332
mRNA Capping pathway
REACT_227775
Transcription-coupled NER (TC-NER) pathway
REACT_205499
RNA Polymerase II Pre-transcription Events pathway
REACT_203707
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_202835
RNA Polymerase II Promoter Escape pathway
REACT_217354
RNA Polymerase I Promoter Escape pathway
REACT_207088
RNA Polymerase I Transcription pathway
REACT_226022
Gene Expression pathway
REACT_212448
Nucleotide Excision Repair pathway
REACT_222458
Global Genomic NER (GG-NER) pathway
REACT_225163
RNA Polymerase I Chain Elongation pathway
REACT_206481
Dual incision reaction in GG-NER pathway
REACT_216254
Formation of transcription-coupled NER (TC-NER) repair complex pathway
REACT_218933
RNA Polymerase II Transcription Elongation pathway
REACT_204262
DNA Repair pathway
REACT_219298
Dual incision reaction in TC-NER pathway
REACT_206737
Formation of RNA Pol II elongation complex pathway
REACT_211596
Formation of incision complex in GG-NER pathway
REACT_208197
RNA Polymerase I Transcription Initiation pathway
REACT_207660
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
REACT_220130
RNA Pol II CTD phosphorylation and interaction with CE pathway
REACT_208384
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
REACT_207656
RNA Polymerase II Transcription Initiation pathway
REACT_219488
RNA Polymerase I Promoter Clearance pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_1074
RNA Polymerase I Transcription Termination pathway
REACT_2204
RNA Polymerase I Chain Elongation pathway
REACT_1913
RNA Polymerase I Promoter Escape pathway
REACT_953
RNA Polymerase I Transcription Initiation pathway
REACT_1470
mRNA Capping pathway
REACT_1655
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
REACT_22107
RNA Polymerase II Pre-transcription Events pathway
REACT_1845
Formation of RNA Pol II elongation complex pathway
REACT_846
Formation of the Early Elongation Complex pathway
REACT_833
RNA Polymerase II Transcription Elongation pathway
REACT_2089
RNA Polymerase II Promoter Escape pathway
REACT_1851
RNA Polymerase II Transcription Initiation pathway
REACT_834
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
REACT_975
RNA Pol II CTD phosphorylation and interaction with CE pathway
REACT_22201
Formation of HIV elongation complex in the absence of HIV Tat pathway
REACT_6332
HIV Transcription Initiation pathway
REACT_6253
RNA Polymerase II HIV Promoter Escape pathway
REACT_6319
Formation of the HIV-1 Early Elongation Complex pathway
REACT_6346
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
REACT_6162
Tat-mediated elongation of the HIV-1 transcript pathway
REACT_6237
RNA Pol II CTD phosphorylation and interaction with CE pathway
REACT_6233
Transcription of the HIV genome pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_1941
Formation of transcription-coupled NER (TC-NER) repair complex pathway
REACT_2222
Dual incision reaction in TC-NER pathway
REACT_1628
Transcription-coupled NER (TC-NER) pathway
REACT_311
Dual incision reaction in GG-NER pathway
REACT_257
Formation of incision complex in GG-NER pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_200856
NoRC negatively regulates rRNA expression pathway
REACT_2253
Global Genomic NER (GG-NER) pathway
REACT_6274
HIV Transcription Elongation pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_1826
Nucleotide Excision Repair pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_216
DNA Repair pathway
REACT_200834
Negative epigenetic regulation of rRNA expression pathway
REACT_230204
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
REACT_213655
Transcription-coupled NER (TC-NER) pathway
REACT_245058
RNA Polymerase I Transcription pathway
REACT_244415
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_203462
Formation of the Early Elongation Complex pathway
REACT_223654
Formation of transcription-coupled NER (TC-NER) repair complex pathway
REACT_240507
Dual incision reaction in GG-NER pathway
REACT_244380
RNA Polymerase II Transcription Initiation pathway
REACT_255334
RNA Polymerase II Promoter Escape pathway
REACT_238177
Global Genomic NER (GG-NER) pathway
REACT_252106
Formation of incision complex in GG-NER pathway
REACT_257165
RNA Polymerase I Transcription Termination pathway
REACT_235422
Nucleotide Excision Repair pathway
REACT_226759
Formation of RNA Pol II elongation complex pathway
REACT_232708
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
REACT_233397
DNA Repair pathway
REACT_226490
RNA Polymerase II Transcription Elongation pathway
REACT_255009
RNA Polymerase II Pre-transcription Events pathway
REACT_258231
mRNA Capping pathway
REACT_233572
Gene Expression pathway
REACT_232235
RNA Polymerase I Promoter Escape pathway
REACT_224562
Dual incision reaction in TC-NER pathway
REACT_240511
RNA Polymerase I Promoter Clearance pathway
REACT_259097
RNA Polymerase I Chain Elongation pathway
REACT_242255
RNA Polymerase II Transcription pathway
REACT_257596
RNA Pol II CTD phosphorylation and interaction with CE pathway
REACT_235780
RNA Polymerase I Transcription Initiation pathway
KEGG
hsa03022
Basal transcription factors pathway
hsa03420
Nucleotide excision repair pathway
mmu03022
Basal transcription factors pathway
mmu03420
Nucleotide excision repair pathway
INOH
PID NCI
Cross-References
SwissProt Q1RMT1
TrEMBL
UniProt Splice Variant
Entrez Gene 507984
UniGene Bt.19954
RefSeq NM_001045988
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114729
GenPept AAI14730
RNA Seq Atlas 507984

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca