Bos taurus Gene: ITGAL | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-639368.2 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | ITGAL | ||||||||||||||||||||||
Gene Name | integrin alpha-L | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000007103 | ||||||||||||||||||||||
Encoded Proteins |
integrin alpha-L
integrin alpha-L
|
||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005844:
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 25:26910424-26961727 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | |||||||||||||||||||||||
Transcripts |
|
||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
|
Gene ID
Gene Order
|
||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Cell surface interactions at the vascular wall pathway
Integrin cell surface interactions pathway
Extracellular matrix organization pathway
Adaptive Immune System pathway
Immune System pathway
Hemostasis pathway
Hemostasis pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Cell surface interactions at the vascular wall pathway
Immune System pathway
Extracellular matrix organization pathway
Integrin cell surface interactions pathway
Adaptive Immune System pathway
|
||||||||||||||||||||||
KEGG |
Regulation of actin cytoskeleton pathway
Cell adhesion molecules (CAMs) pathway
Leukocyte transendothelial migration pathway
Natural killer cell mediated cytotoxicity pathway
Viral myocarditis pathway
Staphylococcus aureus infection pathway
Malaria pathway
Cell adhesion molecules (CAMs) pathway
Natural killer cell mediated cytotoxicity pathway
Regulation of actin cytoskeleton pathway
Leukocyte transendothelial migration pathway
Viral myocarditis pathway
Staphylococcus aureus infection pathway
Malaria pathway
|
||||||||||||||||||||||
INOH |
Integrin signaling pathway pathway
Integrin signaling pathway pathway
|
||||||||||||||||||||||
PID NCI |
Integrin family cell surface interactions
Beta2 integrin cell surface interactions
|
||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | A6QNM4 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 281874 | ||||||||||||||||||||||
UniGene | Bt.64660 | ||||||||||||||||||||||
RefSeq | NM_198221 XM_005224829 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | |||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | BC148897 DAAA02057902 DAAA02057903 DAAA02057904 DAAA02057905 | ||||||||||||||||||||||
GenPept | AAI48898 | ||||||||||||||||||||||
RNA Seq Atlas | 281874 | ||||||||||||||||||||||